[HTML][HTML] An inter-organ neural circuit for appetite suppression
Summary Glucagon-like peptide-1 (GLP-1) is a signal peptide released from
enteroendocrine cells of the lower intestine. GLP-1 exerts anorectic and antimotility actions …
enteroendocrine cells of the lower intestine. GLP-1 exerts anorectic and antimotility actions …
Central and peripheral GLP-1 systems independently suppress eating
The anorexigenic peptide glucagon-like peptide-1 (GLP-1) is secreted from gut
enteroendocrine cells and brain preproglucagon (PPG) neurons, which, respectively, define …
enteroendocrine cells and brain preproglucagon (PPG) neurons, which, respectively, define …
[HTML][HTML] Intestinal glucagon-like peptide-1 effects on food intake: Physiological relevance and emerging mechanisms
JP Krieger - Peptides, 2020 - Elsevier
The gut-brain hormone glucagon-like peptide-1 (GLP-1) has received immense attention
over the last couple of decades for its widespread metabolic effects. Notably, intestinal GLP …
over the last couple of decades for its widespread metabolic effects. Notably, intestinal GLP …
Endogenous hindbrain glucagon-like peptide-1 receptor activation contributes to the control of food intake by mediating gastric satiation signaling
Exogenous activation of central nervous system glucagon-like peptide-1 (GLP-1) receptors
(GLP-1Rs) reduces food intake. Experiments addressed whether endogenous central GLP …
(GLP-1Rs) reduces food intake. Experiments addressed whether endogenous central GLP …
Minireview: the glucagon-like peptides
DJ Drucker - Endocrinology, 2001 - academic.oup.com
The glucagon-like peptides GLP-1 and GLP-2 are produced in enteroendocrine L cells of
the small and large intestine and secreted in a nutrient-dependent manner. GLP-1 regulates …
the small and large intestine and secreted in a nutrient-dependent manner. GLP-1 regulates …
Physiology and pharmacology of the enteroendocrine hormone glucagon-like peptide-2
DJ Drucker, B Yusta - Annual review of physiology, 2014 - annualreviews.org
Glucagon-like peptide-2 (GLP-2) is a 33-amino-acid proglucagon-derived peptide secreted
from enteroendocrine L cells. GLP-2 circulates at low basal levels in the fasting period, and …
from enteroendocrine L cells. GLP-2 circulates at low basal levels in the fasting period, and …
Glucagon-like peptide (GLP)-2 action in the murine central nervous system is enhanced by elimination of GLP-1 receptor signaling
Glucagon-like peptide-2 (GLP-2) regulates energy homeostasis via effects on nutrient
absorption and maintenance of gut mucosal epithelial integrity. The biological actions of …
absorption and maintenance of gut mucosal epithelial integrity. The biological actions of …
[HTML][HTML] The gut hormone glucagon-like peptide-1 produced in brain: is this physiologically relevant?
S Trapp, JE Richards - Current opinion in pharmacology, 2013 - Elsevier
Highlights•PPG neurons express GLP-1 and project to autonomic control sites throughout
the brain.•The distribution of PPG axon terminals mirrors the distribution of GLP-1 receptor …
the brain.•The distribution of PPG axon terminals mirrors the distribution of GLP-1 receptor …
The glucagon‐like peptides: pleiotropic regulators of nutrient homeostasis
PL Brubaker - Annals of the New York Academy of Sciences, 2006 - Wiley Online Library
The glucagon‐like peptides, GLP‐1 and GLP‐2, are cosecreted by intestinal L cells in
response to nutrient ingestion. These peptides exert multiple effects on the gastrointestinal …
response to nutrient ingestion. These peptides exert multiple effects on the gastrointestinal …
Activation of arcuate nucleus glucagon-like peptide-1 receptor-expressing neurons suppresses food intake
Background Central nervous system (CNS) control of metabolism plays a pivotal role in
maintaining energy balance. In the brain, Glucagon-like peptide 1 (GLP-1), encoded by the …
maintaining energy balance. In the brain, Glucagon-like peptide 1 (GLP-1), encoded by the …