Half-sandwich organometallic Ru and Rh complexes of (N, N) donor compounds: Effect of ligand methylation on solution speciation and anticancer activity

JP Mészáros, VFS Pape, G Szakács, G Németi… - Dalton …, 2021 - pubs.rsc.org
A series of half-sandwich polypyridyl complexes was synthesized and compared focusing
on structural, cytotoxic and aqueous solution behaviour. The formula of the synthesized …

Anticancer half-sandwich rhodium (III) complexes

K Máliková, L Masaryk, P Štarha - Inorganics, 2021 - mdpi.com
Platinum-based anticancer drugs are most likely the most successful group of bioinorganic
compounds. Their apparent disadvantages have led to the development of anticancer …

Trinuclear Half‐Sandwich RuII, RhIII and IrIII Polyester Organometallic Complexes: Synthesis and in vitro Evaluation as Antitumor Agents

AR Burgoyne, BCE Makhubela… - European Journal of …, 2015 - Wiley Online Library
Schiff base ligands obtained from the condensation of 4‐aminophenylmethanol and either 2‐
pyridinecarboxaldehyde or salicylaldehyde were used to synthesise bidentate trimeric ester …

Substitution‐Modulated Anticancer Activity of Half‐Sandwich Ruthenium (II) Complexes with Heterocyclic Ancillary Ligands

R Mitra, AG Samuelson - European Journal of Inorganic …, 2014 - Wiley Online Library
Ten new organometallic half‐sandwich ruthenium complexes with heterocyclic ligands have
been synthesized (H1–H10). The substituents on the ancillary heterocyclic ligands were …

Synthesis and evaluation of new polynuclear organometallic Ru (II), Rh (III) and Ir (III) pyridyl ester complexes as in vitro antiparasitic and antitumor agents

P Chellan, KM Land, A Shokar, A Au, SH An… - Dalton …, 2014 - pubs.rsc.org
New polynuclear organometallic Platinum Group Metal (PGM) complexes containing di-and
tripyridyl ester ligands have been synthesised and characterised using analytical and …

Anticancer Activity of Hydrogen‐Bond‐Stabilized Half‐Sandwich RuII Complexes with Heterocycles

R Mitra, S Das, SV Shinde, S Sinha… - … A European Journal, 2012 - Wiley Online Library
Neutral half‐sandwich organometallic ruthenium (II) complexes of the type [(η6‐cymene)
RuCl2 (L)](H1–H10), where L represents a heterocyclic ligand, have been synthesized and …

Organometallic Ru (II), Rh (III) and Re (I) complexes of sterane-based bidentate ligands: synthesis, solution speciation, interaction with biomolecules and anticancer …

T Pivarcsik, MA Kiss, U Rapuš, J Kljun… - Dalton …, 2024 - pubs.rsc.org
In this study, we present the synthesis, characterization and in vitro cytotoxicity of six
organometallic [Ru (II)(η6-p-cymene)(N, N) Cl] Cl,[Rh (III)(η5-C5Me5)(N, N) Cl] Cl and [Re …

Tripodal Half‐Sandwich Rhodium and Iridium Complexes Containing Sulfonate and Pyridinyl Entities as Antitumor Agents

AR Burgoyne, CH Kaschula, MI Parker… - European Journal of …, 2017 - Wiley Online Library
In light of the widely used platinum anticancer drugs showing high toxicity and poor
selectivity, the quest to develop new anticancer agents is increasing. This study investigated …

Tuning the Hydrolytic Properties of Half‐Sandwich‐Type Organometallic Cations in Aqueous Solution

L Bíró, AJ Godó, Z Bihari, E Garribba… - European Journal of …, 2013 - Wiley Online Library
Hydrolysis of half‐sandwich‐type platinum metal cations with the general formula [M (η6‐
arene)(H2O) 3] 2+{M= Ru, Os; η6‐arene= benzene, toluene, 1‐methyl‐4‐isopropylbenzene …

Influence of the Arene Ligand, the Number and Type of Metal Centers, and the Leaving Group on the in Vitro Antitumor Activity of Polynuclear Organometallic …

MG Mendoza-Ferri, CG Hartinger, AA Nazarov… - …, 2009 - ACS Publications
Dinuclear ruthenium complexes were shown to exhibit strong antiproliferative properties in
human tumor cell lines. In order to extend the structure− activity relationships (SARs), a …