In recent years, microphysiological system (MPS, also known as, organ-on-a-chip or tissue
chip) platforms have emerged with great promise to improve the predictive capacity of …

Organ-on-a-chip devices, also known as microphysiological systems, have gained
significant attention in recent years. Recent advances in tissue engineering and …

Summary Microphysiological systems (MPSs)(ie, tissue or organ chips) exploit microfluidics
and 3D cell culture to mimic tissue and organ-level physiology. The advent of human …

Vascular diseases, such as atherosclerosis and thrombosis, are major causes of morbidity
and mortality worldwide. Traditional in vitro models for studying vascular diseases have …

Current biomedical models fail to replicate the complexity of human biology. Consequently,
almost 90% of drug candidates fail during clinical trials after decades of research and …

Highlights•Physiologically relevant organ models based on microfabrication and
bioengineering.•Recent progress on organ-on-a-chip systems simulating kidney, brain, lung …

Microphysiological systems (MPS), also known as organ-on-a-chip technology, combine cell
culture models and microtechnology to mimic tissue microenvironment and provide …

Microphysiological systems have emerged in the last decade to provide an alternative to in
vivo models in basic science and pharmaceutical research. In the field of vascular biology, in …

Microphysiological systems (MPS), consisting of interacting organs-on-chips or tissue-
engineered, 3D organ constructs that use human cells, present an opportunity to bring new …

Physiologically based pharmacokinetic (PBPK) modeling and simulation approaches are
beginning to be integrated into drug development and approval processes because they …