HEXIM1 is an essential transcription regulator during human erythropoiesis
Regulation of RNA polymerase II (RNAPII) activity is an essential process that governs gene
expression; however, its contribution to the fundamental process of erythropoiesis remains …
expression; however, its contribution to the fundamental process of erythropoiesis remains …
Regulation of RNA polymerase II activity is essential for terminal erythroid maturation
The terminal maturation of human erythroblasts requires significant changes in gene
expression in the context of dramatic nuclear condensation. Defects in this process are …
expression in the context of dramatic nuclear condensation. Defects in this process are …
Meis1, Hi1α, and GATA1 are integrated into a hierarchical regulatory network to mediate primitive erythropoiesis
HY Chung, BA Lin, YX Lin, CW Chang… - The FASEB …, 2021 - Wiley Online Library
During development, erythroid cells are generated by two waves of hematopoiesis. In
zebrafish, primitive erythropoiesis takes place in the intermediate cell mass region, and …
zebrafish, primitive erythropoiesis takes place in the intermediate cell mass region, and …
Hemogen/BRG1 cooperativity modulates promoter and enhancer activation during erythropoiesis
X Guo, Y Zhao, J Kim, A Dean - Blood, The Journal of the …, 2022 - ashpublications.org
Hemogen is a hematopoietic tissue–specific gene that regulates the proliferation and
differentiation of hematopoietic cells; however, the mechanism underlying its function in …
differentiation of hematopoietic cells; however, the mechanism underlying its function in …
Homeodomain-interacting protein kinase 2 plays an important role in normal terminal erythroid differentiation
SM Hattangadi, KA Burke… - Blood, The Journal of the …, 2010 - ashpublications.org
Gene-targeting experiments report that the homeodomain-interacting protein kinases 1 and
2, Hipk1 and Hipk2, are essential but redundant in hematopoietic development because …
2, Hipk1 and Hipk2, are essential but redundant in hematopoietic development because …
The novel GATA1-interacting protein HES6 is an essential transcriptional cofactor for human erythropoiesis
Z Wang, P Wang, J Zhang, H Gong… - Nucleic Acids …, 2023 - academic.oup.com
Normal erythropoiesis requires the precise regulation of gene expression patterns, and
transcription cofactors play a vital role in this process. Deregulation of cofactors has …
transcription cofactors play a vital role in this process. Deregulation of cofactors has …
Heme as a differentiation-regulatory transcriptional cofactor
R Liao, EH Bresnick - International journal of hematology, 2022 - Springer
The hematopoietic transcription factor GATA1 induces heme accumulation during
erythropoiesis by directly activating genes mediating heme biosynthesis. In addition to its …
erythropoiesis by directly activating genes mediating heme biosynthesis. In addition to its …
Single-cell analyses demonstrate that a heme–GATA1 feedback loop regulates red cell differentiation
RT Doty, X Yan, C Lausted, AD Munday… - Blood, The Journal …, 2019 - ashpublications.org
Erythropoiesis is the complex, dynamic, and tightly regulated process that generates all
mature red blood cells. To understand this process, we mapped the developmental …
mature red blood cells. To understand this process, we mapped the developmental …
HIF-1 directly induces TET3 expression to enhance 5-hmC density and induce erythroid gene expression in hypoxia
JZ Cao, H Liu, A Wickrema, LA Godley - Blood advances, 2020 - ashpublications.org
In mammalian cells, cytosines found within cytosine guanine dinucleotides can be
methylated to 5-methylcytosine (5-mC) by DNA methyltransferases and further oxidized by …
methylated to 5-methylcytosine (5-mC) by DNA methyltransferases and further oxidized by …
GATA-1 Utilizes Ikaros and Polycomb Repressive Complex 2 To Suppress Hes1 and To Promote Erythropoiesis
J Ross, L Mavoungou, EH Bresnick… - Molecular and cellular …, 2012 - Taylor & Francis
The transcription factor Hairy Enhancer of Split 1 (HES1), a downstream effector of the Notch
signaling pathway, is an important regulator of hematopoiesis. Here, we demonstrate that in …
signaling pathway, is an important regulator of hematopoiesis. Here, we demonstrate that in …