Regulation of RNA polymerase II (RNAPII) activity is an essential process that governs gene
expression; however, its contribution to the fundamental process of erythropoiesis remains …

The terminal maturation of human erythroblasts requires significant changes in gene
expression in the context of dramatic nuclear condensation. Defects in this process are …

During development, erythroid cells are generated by two waves of hematopoiesis. In
zebrafish, primitive erythropoiesis takes place in the intermediate cell mass region, and …

Hemogen is a hematopoietic tissue–specific gene that regulates the proliferation and
differentiation of hematopoietic cells; however, the mechanism underlying its function in …

Gene-targeting experiments report that the homeodomain-interacting protein kinases 1 and
2, Hipk1 and Hipk2, are essential but redundant in hematopoietic development because …

Normal erythropoiesis requires the precise regulation of gene expression patterns, and
transcription cofactors play a vital role in this process. Deregulation of cofactors has …

The hematopoietic transcription factor GATA1 induces heme accumulation during
erythropoiesis by directly activating genes mediating heme biosynthesis. In addition to its …

Erythropoiesis is the complex, dynamic, and tightly regulated process that generates all
mature red blood cells. To understand this process, we mapped the developmental …

In mammalian cells, cytosines found within cytosine guanine dinucleotides can be
methylated to 5-methylcytosine (5-mC) by DNA methyltransferases and further oxidized by …

The transcription factor Hairy Enhancer of Split 1 (HES1), a downstream effector of the Notch
signaling pathway, is an important regulator of hematopoiesis. Here, we demonstrate that in …