Abstract Next-Generation Risk Assessment is defined as an exposure-led, hypothesis-driven
risk assessment approach that integrates new approach methodologies (NAMs) to assure …

This paper presents a 10-step read-across (RAX) framework for use in cases where a
threshold of toxicological concern (TTC) approach to cosmetics safety assessment is not …

Risk assessment of cosmetic ingredients is a useful scientific method to characterize
potential adverse effects resulting from using cosmetics. The process of risk assessment …

Consumer safety is a prerequisite for any cosmetic product. Worldwide, there is an ever-
increasing desire to bring safe products to market without animal testing, which requires a …

Next generation risk assessment (NGRA) is an exposure-led, hypothesis-driven approach
that has the potential to support animal-free safety decision-making. However, significant …

All cosmetic products placed onto the market must undergo a risk assessment for human
health to ensure they are safe for consumers, including an assessment of skin sensitisation …

Coumarin (1, 2-benzopyrone) is a naturally occurring fragrant compound found in a variety
of plants and spices. Exposure to the general public is through the diet and from its use as a …

In silico tools and resources are now used commonly in toxicology and to support the “Next
Generation Risk Assessment”(NGRA) of cosmetics ingredients or materials. This review …

According to the current European legislation, the safety assessment of each individual
cosmetic ingredient of any formulation is the basis for the safety evaluation of a cosmetic …

Access to reliable exposure data is essential to evaluate the toxicological safety of
ingredients in cosmetic products. This study was carried out by European cosmetic …