Isorhapontigenin attenuates cardiac microvascular injury in diabetes via the inhibition of mitochondria-associated ferroptosis through PRDX2-MFN2-ACSL4 pathways

Y Chen, S Li, M Yin, Y Li, C Chen, J Zhang, K Sun… - Diabetes, 2023 - Am Diabetes Assoc
Ferroptosis is a newly identified form of regulated cell death that is driven by iron overload
and uncontrolled lipid peroxidation, but the role of ferroptosis in cardiac microvascular …

[HTML][HTML] Nicorandil alleviates cardiac microvascular ferroptosis in diabetic cardiomyopathy: Role of the mitochondria-localized AMPK-Parkin-ACSL4 signaling pathway

Z Chen, S Li, M Liu, M Yin, J Chen, Y Li, Q Li… - Pharmacological …, 2024 - Elsevier
Mitochondria-associated ferroptosis exacerbates cardiac microvascular dysfunction in
diabetic cardiomyopathy (DCM). Nicorandil, an ATP-sensitive K+ channel opener, protects …

Curcumin attenuates ferroptosis‐induced myocardial injury in diabetic cardiomyopathy through the Nrf2 pathway

Z Wei, Q Shaohuan, K Pinfang… - Cardiovascular …, 2022 - Wiley Online Library
Diabetes causes lipid peroxide to accumulate within cardiomyocytes. Furthermore, lipid
peroxide buildup is a risk factor for ferroptosis. This study is aimed at examining whether …

[HTML][HTML] Ferroptosis is essential for diabetic cardiomyopathy and is prevented by sulforaphane via AMPK/NRF2 pathways

X Wang, X Chen, W Zhou, H Men, T Bao, Y Sun… - … Pharmaceutica Sinica B, 2022 - Elsevier
Herein, we define the role of ferroptosis in the pathogenesis of diabetic cardiomyopathy
(DCM) by examining the expression of key regulators of ferroptosis in mice with DCM and a …

[HTML][HTML] Atorvastatin Induces Mitochondria-Dependent Ferroptosis via the Modulation of Nrf2-xCT/GPx4 Axis

Q Zhang, H Qu, Y Chen, X Luo, C Chen… - Frontiers in Cell and …, 2022 - frontiersin.org
As one of the cornerstones of clinical cardiovascular disease treatment, statins have an
extensive range of applications. However, statins commonly used have side reactions …

[HTML][HTML] Iron accumulation and lipid peroxidation: implication of ferroptosis in diabetic cardiomyopathy

X Yan, Y Xie, H Liu, M Huang, Z Yang, D An… - Diabetology & Metabolic …, 2023 - Springer
Diabetic cardiomyopathy (DC) is a serious heart disease caused by diabetes. It is unrelated
to hypertension and coronary artery disease and can lead to heart insufficiency, heart failure …

[HTML][HTML] Puerarin-V improve mitochondrial respiration and cardiac function in a rat model of diabetic cardiomyopathy via inhibiting pyroptosis pathway through P2X7 …

S Sun, A Dawuti, D Gong, R Wang, T Yuan… - International journal of …, 2022 - mdpi.com
There is a new form of puerarin, puerarin-V, that has recently been developed, and it is
unclear whether puerarin-V has a cardioprotective effect on diabetic cardiomyopathy (DCM) …

Atorvastatin treatment ameliorates cardiac function and remodeling induced by isoproterenol attack through mitigation of ferroptosis

D Ning, X Yang, T Wang, Q Jiang, J Yu… - … and Biophysical Research …, 2021 - Elsevier
Ferroptosis has been identified as an important role in damaged heart. Meanwhile, statin
therapy has been reported to be beneficial for the treatment of heart failure (HF) under …

[HTML][HTML] Mechanisms of ferroptosis regulating oxidative stress and energy metabolism in myocardial ischemia-reperfusion injury and a novel perspective of natural …

T Zhang, W Deng, Y Deng, Y Liu, S Xiao, Y Luo… - Biomedicine & …, 2023 - Elsevier
Acute myocardial infarction remains the leading cause of death in humans. Timely
restoration of blood perfusion to ischemic myocardium remains the most effective strategy in …

[HTML][HTML] Nobiletin alleviates myocardial ischemia-reperfusion injury via ferroptosis in rats with type-2 diabetes mellitus

Q Huang, L Tian, Y Zhang, Z Qiu, S Lei… - Biomedicine & …, 2023 - Elsevier
Susceptibility to myocardial ischemia-reperfusion (IR) injury in type-2 diabetes (T2DM)
remains disputed, although studies have reported that ferroptosis is associated with …