Hemophilic arthropathy (HA) is a debilitating degenerative joint disease that is a major
manifestation of the bleeding disorder hemophilia A. HA typically begins with hemophilic …

One of the main complications of haemophilia A is haemophilic arthropathy (HA), a
debilitating disease with a significant negative impact on motility and quality of life. Despite …

While joint damage is the primary co-morbidity of hemophilia, osteoporosis and osteopenia
are also observed. Coagulation factor VIII deficient (FVIII−/−) mice develop an osteoporotic …

Background The present study was designed to investigate the molecular signaling events
from onset of bleeding through the development of arthropathy in a murine model of …

Background Mechanisms of iron clearance from hemophilic joints are unknown. Objectives
To better understand mechanisms of iron clearance following joint bleeding in a mouse …

Essentials• Validating the F8 rat as a new intermediate‐size animal model of hemophilic
arthropathy.• Factor VIII (FVIII) treated F8−/− rats suffered induced hemarthrosis analyzed by …

Despite an increasing access to prophylaxis with clotting factor concentrates, arthropathy
still represents the main chronic complication of hemophilia. Whereas previous studies …

Hemophilic arthropathy (HA) due to repeated bleeding into the joint cavity is a major cause
of morbidity in patients with hemophilia. The molecular mechanisms contributing to this …

Hemophilia is a congenital clotting factor deficiency characterized by spontaneous and
trauma-related bleeding. Spontaneous bleeding shows a predilection for joints, and …

Hemophilic arthropathy is a debilitating condition that can develop as a consequence of
frequent joint bleeding despite adequate clotting factor replacement. The mechanisms …