Immune checkpoint inhibitors have achieved significant clinical success but are still suffering
from inadequate immune activation. It is worth noting that manganese as a nutritional …

Radiotherapy (RT), as one of the main methods in the clinical treatment of various malignant
tumors, would induce systemic immunotherapeutic effects by triggering immunogenic cell …

Immunotherapies have shown high clinical success, however, the therapeutical efficacy is
largely restrained by insufficient immune activation and an immunosuppressive …

Development of a nanoscale drug delivery system that can simultaneously exert efficient
tumor therapeutic efficacy while creating the desired antitumor immune responses is still …

As an essential micronutrient, manganese (Mn) participates in various physiological
processes and plays important roles in host immune system, hematopoiesis, endocrine …

Cyclic GMP-AMP synthase (cGAS) and stimulator of interferon genes (STING) are essential
components of the innate immune sensors to cytosolic DNA and elicit type I interferon (IFN) …

Ions play a vital role in regulating various biological processes, including metabolic and
immune homeostasis, which involves tumorigenesis and therapy. Thus, the perturbation of …

Immune checkpoint blockers therapy can improve the radiotherapy‐induced
immunosuppression by enhancing interferon secretion, but still suffer from low clinical …

Artificially modulating the type, density, and location of immune cells within the tumor
microenvironment can suppress tumor growth and efficiently promote current …

Certain types of cationic metal ions, such as Mn 2+ are able to activate immune functions via
the stimulator of interferon genes (STING) pathway, showing potential applications in …