Exposure to asbestos, particularly members of the amphibole subgroup (crocidolite,
amosite), is associated with the development of malignant mesothelioma and lung cancer …

A striking synergistic effect on tumor induction is seen when asbestos and polycyclic
hydrocarbons (PCH) are inhaled by or instilled intratracheally into rodents. This observation …

Respiratory exposure to asbestos fibers has been associated with diffuse malignant
mesothelioma (DMM) in humans. Despite advancements in the molecular analyses of …

Asbestos fibers may exert their carcinogenic effects on mesothelial cells and bronchial
epithelial cells by direct and indirect mechanisms. Direct effects can occur following the …

Asbestos comprises a group of fibrous minerals that are naturally occurring in the
environment. Because of its natural properties, asbestos gained popularity for commercial …

Mechanisms of asbestos (1332214) respiratory toxicity and carcinogenicity are discussed.
Physicochemical properties of asbestos are summarized. Toxic effects of asbestos are …

Asbestos is a well-known toxin and lung carcinogen. Epidemiologic studies have
established tobacco smoke and asbestos exposures synergistically interact to enhance lung …

Carcinogenic agents can influence the carcinogenic process either by mutating critical target
genes or by increasing the number of cells at risk for mutations. Cytogenetic and molecular …

Asbestos is one of the most important occupational carcinogens. Currently, about 125
million people worldwide are exposed to asbestos in the workplace. According to global …

Lung carcinomas and pulmonary fibrosis (asbestosis) occur in asbestos workers.
Understanding the pathogenesis of these diseases is complicated because of potential …