Current pharmacologic treatments may provide limited analgesia in fibromyalgia and other
chronic pain disorders. Low-dose naltrexone (LDN) has emerged as a potential analgesic …

Purpose Low-dose naltrexone (LDN) has increased in popularity as a non-opioid
medication that may decrease chronic pain symptoms. LDN is most commonly used to treat …

Objective To determine whether low dosages (4.5 mg/day) of naltrexone reduce
fibromyalgia severity as compared with the nonspecific effects of placebo. In this replication …

Objectives: First, to examine if LDN is associated with analgesic efficacy compared with
control in the treatment of patients with FM. Second, to ascertain the analgesic efficacy of …

Abstract Purpose of Review The purpose of this review is to evaluate and explain our current
understanding of the clinical use of low-dose naltrexone in the treatment of chronic pain …

Background Low dose naltrexone (LDN) is used off-label by many individuals with
fibromyalgia to help manage their pain. There is no current systematic literature review …

Fibromyalgia (FM) is a chronic pain sensitivity syndrome characterized by diffuse
musculoskeletal pain and many other systemic manifestations. Low-dose naltrexone (LDN) …

Background At low doses, naltrexone (LDN) has been shown to modulate inflammation
through the interruption of microglial cell activation within the central nervous system. One of …

Aim: To evaluate the use of low-dose naltrexone (LDN) as a broad-spectrum analgesic.
Methods: Retrospective cohort study from a single pain management practice using data …

Objective. Fibromyalgia is a chronic pain disorder that is characterized by diffuse
musculoskeletal pain and sensitivity to mechanical stimulation. In this pilot clinical trial, we …