Injury or disease to the CNS results in multifaceted cellular and molecular responses. One
such response, the glial scar, is a structural formation of reactive glia around an area of …

Astrocytes react to CNS injury by building a dense wall of filamentous processes around the
lesion. Stromal cells quickly take up residence in the lesion core and synthesize connective …

Scar formation represents a reaction of nervous tissue to any form of physical injury.
Research over the past decade has demonstrated that the scar composed of glial cells and …

Astrocytes respond to central nervous system (CNS) injury with reactive astrogliosis and
participate in the formation of the glial scar, an inhibitory barrier for axonal regeneration …

Traumatic injury to the adult central nervous system (CNS) results in a rapid response from
resident astrocytes, a process often referred to as reactive astrogliosis or glial scarring. The …

Severe spinal cord injury causes permanent loss of function and sensation throughout the
body. The trauma causes a multifaceted torrent of pathophysiological processes which …

Damage to the central nervous system (CNS) results in a glial reaction, leading eventually to
the formation of a glial scar. In this environment, axon regeneration fails, and remyelination …

Reactive gliosis, also known as glial scar formation, is an inflammatory response
characterized by the proliferation of microglia and astrocytes as well as astrocytic …

Following CNS injury, in an apparently counterintuitive response, scar tissue formation
inhibits axonal growth, imposing a major barrier to regeneration. Accordingly, scar …

Glial scarring following severe tissue damage and inflammation after spinal cord injury (SCI)
is due to an extreme, uncontrolled form of reactive astrogliosis that typically occurs around …