Rationale: Aging is one of the strongest risk factors for atherosclerosis. Yet whether aging
increases the risk of atherosclerosis independently of chronic hyperlipidemia is not known …

The number of old people is rising worldwide, and advancing age is a major risk factor for
atherosclerotic cardiovascular disease. However, the mechanisms underlying this …

Mitochondrial biogenesis is involved in the control of cell metabolism, signal transduction,
and regulation of mitochondrial reactive oxygen species (ROS) production. Despite the …

Rationale—Mitochondrial oxidative stress (mitoOS) has been shown to be increased in
various cell types in human atherosclerosis and with aging. However, the role of cell type …

Key points The development of age‐related arterial endothelial dysfunction, a key
antecedent of increased cardiovascular disease (CVD) risk, is mediated largely by reduced …

Mitochondria are often regarded as the powerhouse of the cell by generating the ultimate
energy transfer molecule, ATP, which is required for a multitude of cellular processes …

The heart is dependent on ATP production in mitochondria, which is closely associated with
cardiovascular disease because of the oxidative stress produced by mitochondria …

Mitophagy is a critical cellular process that selectively targets damaged mitochondria for
autophagosomal degradation both under baseline conditions and in response to stress …

Advanced age is associated with a disproportionate prevalence of cardiovascular disease
(CVD). Intrinsic alterations in the heart and the vasculature occurring over the life course …

Cardiovascular diseases (CVD) are the leading cause of death worldwide and aging is the
primary risk factor for CVD. The development of vascular dysfunction, including endothelial …