Malaria continues to exert a tremendous health burden on human populations, reflecting
astonishingly successful adaptations of the causative Plasmodium parasites. We discuss …

Malaria has been invoked, perhaps more than any other infectious disease, as a force for
the selection of human genetic polymorphisms. Evidence for genome-shaping interactions …

Plasmodium falciparum malaria kills over 500,000 children every year and has been a
scourge of humans for millennia. Owing to the co-evolution of humans and P. falciparum …

The malaria threat to global health is exacerbated by widespread drug resistance in the
Plasmodium parasite and its insect vector, and the lack of an efficacious vaccine. Infection …

The Plasmodium parasite successfully infects and replicates in both human and insect
vectors. Population studies in humans have long detected the enormous selective pressure …

Malaria, which is a major infectious disease worldwide, is caused by the Plasmodium
parasite, one of the longest-known parasites infecting humans. The malaria situation is …

Protective hemoglobinopathies and Plasmodium falciparum transmission | Nature Genetics
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Why does Plasmodium falciparum cause severe illness in some but not all infections? How
is clinical immunity acquired? These questions have intrigued investigators since the clinical …

Populations exposed to Plasmodium infection develop genetic mechanisms of protection
against severe disease. The clinical manifestation of malaria results primarily from the lysis …

Plasmodium falciparum is the etiological agent of malaria tropica, the leading cause of death
due to a vector-borne infectious disease, claiming 0.5 million lives every year. The single …