Nakagawa and Sigmund Regulation of the Brain RAS 11 processing proteases including
tonin and cathepsin G with a broad spectrum of substrate affinities. 27 Ang-(1–12), a peptide …

Publisher Summary This chapter discusses the recent progress made in the molecular
genetics of the renin–angiotensin system genes with a special emphasis on human …

The renin–angiotensin system (RAS) in the brain is a critical determinant of blood pressure,
but the mechanisms regulating RAS activity in the brain remain unclear. Expression of brain …

Since the first description of renin, angiotensinogen and angiotensin as well as converting
enzyme and angiotensin receptors in the brain exactly 30 years ago, 1–5 there was a …

The brain renin–angiotensin system is implicated in the regulation of blood pressure (BP)
and fluid homeostasis. Recent studies reveal that 2 forms of renin are expressed in the brain …

Objective: To evaluate the possible role of tissue renin overproduction in the pathogenesis
and time course of hypertension development in the spontaneously hypertensive rat (SHR) …

The renin-angiotensin system (RAS), known for its roles in cardiovascular, metabolic, and
developmental regulation, is present in both the circulation and in many individual tissues …

Because of the presence of the blood–brain barrier, brain renin–angiotensin system activity
should depend on local (pro) renin synthesis. Indeed, an intracellular form of renin has been …

An indispensable role for the brain renin-angiotensin system (RAS) has been documented
in most experimental animal models of hypertension. To identify the specific efferent …

1008 Hypertension June 2017 renin, angiotensin-converting enzyme, and the angiotensin
type 1 receptor in the brain. Thus, these data, which did not involve any exogenous …