PACAP6-38 improves nitroglycerin-induced central sensitization by modulating synaptic plasticity at the trigeminal nucleus caudalis in a male rat model of chronic …
L Zhang, Y Zhou, L Yang, Y Wang, Z Xiao - The Journal of Headache and …, 2023 - Springer
Aims Chronic migraine (CM) is a common neurological disorder with complex pathogenesis.
Evidence suggests that pituitary adenylate cyclase-activating peptide (PACAP) induces …
Evidence suggests that pituitary adenylate cyclase-activating peptide (PACAP) induces …
Inhibiting PAC1 receptor internalization and endosomal ERK pathway activation may ameliorate hyperalgesia in a chronic migraine rat model
L Zhang, Y Zhou, Y Wang, L Yang, Y Wang… - …, 2023 - journals.sagepub.com
Background Pituitary adenylate cyclase-activating polypeptide (PACAP) is a multipotent
neuropeptide widely distributed in the trigeminovascular system (TVS) and higher brain …
neuropeptide widely distributed in the trigeminovascular system (TVS) and higher brain …
PACAP signaling is not involved in GTN-and levcromakalim-induced hypersensitivity in mouse models of migraine
S Guo, C Ernstsen, A Hay-Schmidt… - The Journal of …, 2022 - Springer
Background Calcitonin gene-related peptide (CGRP) antagonizing drugs represents the
most important advance in migraine therapy for decades. However, these new drugs are …
most important advance in migraine therapy for decades. However, these new drugs are …
Dynamic changes in CGRP, PACAP, and PACAP receptors in the trigeminovascular system of a novel repetitive electrical stimulation rat model: Relevant to migraine
Q Zhang, X Han, H Wu, M Zhang, G Hu… - Molecular …, 2019 - journals.sagepub.com
Migraine is the seventh most disabling disorder globally, with prevalence of 11.7%
worldwide. One of the prevailing mechanisms is the activation of the trigeminovascular …
worldwide. One of the prevailing mechanisms is the activation of the trigeminovascular …
The effect of orofacial complete Freund's adjuvant treatment on the expression of migraine-related molecules
Background Migraine is a neurovascular primary headache disorder, which causes
significant socioeconomic problems worldwide. The pathomechanism of disease is …
significant socioeconomic problems worldwide. The pathomechanism of disease is …
The PACAP receptor: a novel target for migraine treatment
The origin of migraine pain has not yet been clarified, but accumulating data point to
neuropeptides present in the perivascular space of cranial vessels as important mediators of …
neuropeptides present in the perivascular space of cranial vessels as important mediators of …
Shared and independent roles of CGRP and PACAP in migraine pathophysiology
A Kuburas, AF Russo - The Journal of Headache and Pain, 2023 - Springer
The neuropeptides calcitonin gene-related peptide (CGRP) and pituitary adenylate cyclase-
activating polypeptide (PACAP) have emerged as mediators of migraine pathogenesis. Both …
activating polypeptide (PACAP) have emerged as mediators of migraine pathogenesis. Both …
The PACAP pathway is independent of CGRP in mouse models of migraine: possible new drug target?
C Ernstsen, SL Christensen, RH Rasmussen… - Brain, 2022 - academic.oup.com
Calcitonin gene-related peptide (CGRP)-antagonizing drugs represent a major advance in
migraine treatment. However, up to 50% of patients do not benefit from monoclonal …
migraine treatment. However, up to 50% of patients do not benefit from monoclonal …
Differences in pituitary adenylate cyclase-activating peptide and calcitonin gene-related peptide release in the trigeminovascular system
JCA Edvinsson, AS Grell, K Warfvinge… - …, 2020 - journals.sagepub.com
Background Several neurotransmitters are expressed in the neurons of the trigeminal
ganglion. One such signalling molecule is the pituitary adenylate cyclase-activating peptide …
ganglion. One such signalling molecule is the pituitary adenylate cyclase-activating peptide …
PACAP-38 but not VIP induces release of CGRP from trigeminal nucleus caudalis via a receptor distinct from the PAC1 receptor
I Jansen-Olesen, M Baun, DV Amrutkar… - Neuropeptides, 2014 - Elsevier
Objective To investigate if PACAP and VIP have an effect on CGRP release or NOS activity
in the trigeminal ganglion and trigeminal nucleus caudalis and if there can be a difference in …
in the trigeminal ganglion and trigeminal nucleus caudalis and if there can be a difference in …
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