Identification of hub genes associated with spermatogenesis by bioinformatics analysis

S Liu, Y Bian, W Wang, TJ Liu, T Zhang, Y Chang… - Scientific Reports, 2023 - nature.com
Spermatogenesis is a complex process related to male infertility. Till now, the critical genes
and specific mechanisms have not been elucidated clearly. Our objective was to determine …

Identification and functional analysis of spermatogenesis‐associated gene modules in azoospermia by weighted gene coexpression network analysis

W Zheng, Z Zou, S Lin, X Chen, F Wang… - Journal of cellular …, 2019 - Wiley Online Library
Nonobstructive azoospermia (NOA) or testicular failure is the most severe form of male
infertility. A variety of conditions, both acquired and congenital, can cause azoospermia …

The novel key genes of non-obstructive azoospermia affect spermatogenesis: transcriptomic analysis based on RNA-Seq and scRNA-Seq data

H He, F Yu, W Shen, K Chen, L Zhang, S Lou… - Frontiers in …, 2021 - frontiersin.org
Non-obstructive azoospermia (NOA) is one of the most important causes of male infertility. It
is mainly characterized by the absence of sperm in semen repeatedly or the number of …

Integrated molecular-network analysis reveals infertility-associated key genes and transcription factors in the non-obstructive azoospermia

DB Alagundagi, SD Ghate, P Shetty, P Gollapalli… - European Journal of …, 2023 - Elsevier
Background Male infertility is a multifactorial reproductive health problem with complex
causes. Non-obstructive azoospermia (NOA) is characterized by failure of spermatogenesis …

Role of hub genes in the occurrence and development of testicular cancer based on bioinformatics

C Zhang, W Zhang, H Cui, B Zhang… - … journal of general …, 2022 - Taylor & Francis
Background Testicular cancer severely affects male health, so finding effective diagnosis
and prognostic indicators and exploring its pathogenesis are very important. Purpose This …

[HTML][HTML] Identification of potential core genes and miRNAs in testicular seminoma via bioinformatics analysis

K Wang, Y Chen, Z Zhao… - Molecular Medicine …, 2019 - spandidos-publications.com
Testicular seminoma is one of the most common tumours in the field of urology, and its
aetiology is still unclear. The aim of the present study was to identify the factors responsible …

Bioinformatics analysis identifies potential hub genes and crucial pathways in the pathogenesis of asthenozoospermia

C Zou, S Xu, H Geng, E Li, W Sun, D Yu - BMC Medical Genomics, 2022 - Springer
Background Asthenozoospermia is a troublesome disease experienced by men in their
reproductive years, but its exact etiology remains unclear. To address this problem, this …

Integrative analyses of potential biomarkers and pathways for non-obstructive azoospermia

Y Zhong, X Chen, J Zhao, H Deng, X Li, Z Xie… - Frontiers in …, 2022 - frontiersin.org
Background: Non-obstructive azoospermia (NOA) is the most severe form of male infertility.
Currently, the molecular mechanisms underlying NOA pathology have not yet been …

[HTML][HTML] Identification and potential value of candidate genes in patients with non-obstructive azoospermia

Y Shen, X Wu, Q Li, X Huang, J Wang, L Zhao, T Zhang… - Urology, 2022 - Elsevier
Objectives To explore the candidate genes involved in the pathogenesis of non-obstructive
azoospermia (NOA) using bioinformatics analysis and experimental verification. Methods …

Whole exome sequencing and in silico analysis of human Sertoli in patients with non-obstructive azoospermia

H Azizi, D Hashemi Karoii, T Skutella - International Journal of Molecular …, 2022 - mdpi.com
Non-obstructive azoospermia (NOA) is a serious cause of male infertility. The Sertoli cell
responds to androgens and takes on roles supporting spermatogenesis, which may cause …