The intracellular production of reactive oxygen species (ROS), composed of oxygen-
reduced molecules, is important not only because of their lethal effects on microorganisms …

Highlights•Functional degradation is an essential step in NLRP1b inflammasome
activation.•Site-specific cleavage of caspase-11/4/5 generates an enzymatically active …

Inflammasomes form a crucial part of the innate immune system. These are multi-protein
oligomer platforms that are composed of intracellular sensors which are coupled with …

Innate immunity is a crucial part of the immune system, capable of mounting specific host
responses against distinct pathogens. An integral component of the innate immune system …

Host defense responses against microbes are most often thought of in terms of effectors of
microbial destruction. However, recent evidence demonstrates that the more complex …

Inflammasomes are cytosolic multiprotein complexes that assemble in response to a variety
of infectious and noxious insults. Inflammasomes play a critical role in the initiation of innate …

Inflammasomes are signalling platforms that sense a diverse range of microbial products
and also a number of stress and damage associated endogenous signals. Inflammasome …

The immune system of multicellular organisms protects them from harmful microbes. To
establish an infection in the face of host immune responses, pathogens must evolve specific …

Activation of the inflammasome occurs in response to a notably high number of pathogenic
microbes and is a broad innate immune response that effectively contributes to restriction of …

Highlights•The innate immune system utilizes a set of multiprotein complexes called
inflammasomes that can be triggered during infection.•Inflammasome activation supports …