Effective drug delivery and prevention of postoperative recurrence are significant challenges
for current glioblastoma (GBM) treatment. Poor drug delivery is mainly due to the presence …

Glioblastoma multiforme (GBM) is the most aggressive tumor of the central nervous system
in adults. The standard therapy of GBM fails to eradicate it due to the drug resistance of …

Clinical treatment of malignant glioma remains a major challenge due to high infiltrative
growth and chemotherapeutic resistance of tumors and the presence of the blood brain …

Exosomes are natural delivery vehicles because of their original feature such as low
immunogenicity, excellent biocompatibility, and migration capability. Engineering exosomes …

Successful cancer therapy requires drugs being precisely delivered to tumors. Nanosized
drugs have attracted considerable recent attention, but their toxicity and high …

Exosomes (Exos) as drug delivery vehicles have been widely used for cancer
immunotherapy owing to their good biocompatibility, low toxicity, and low immunogenicity …

Recently, combination immunotherapy, which incorporates the activation of the immune
system and inhibition of immune escape, has been proved to be a new powerful strategy for …

Exosomes, the cell-derived small extracellular vehicles, play a vital role in intracellular
communication by reciprocally transporting DNA, RNA, bioactive protein, chains of glucose …

Despite the promising potential of cancer vaccine, their efficacy has been limited in clinical
trials and improved methods are urgently needed. Here we designed a nanovaccine …

Despite multiple immunotherapeutic technologies that achieve potent T cell activation,
effector T cells still lack efficiency because of the highly immunosuppressive conditions in …