Here, we report the effect of new non-classical bioisosteres of miltefosine on Leishmania
amazonensis. Fifteen compounds were synthesized and the compound dhmtAc, containing …

A series of pyrazolo (dihydro) pyridines was synthesized and evaluated for antileishmanial
efficacy against experimental visceral leishmaniasis (VL). Among all compounds, 6d and 6j …

Miltefosine causes leishmanial death, but the possible mechanism (s) of action is not known.
The mode of action of miltefosine was investigated in vitro in Leishmania donovani …

In the current study, we evaluated the mechanism of action of miltefosine, which is the first
effective and safe oral treatment for visceral leishmaniasis, in Leishmania amazonensis …

ABSTRACT Miltefosine (hexadecylphosphocholine [HePC]) has proved to be a potent oral
treatment for human visceral leishmaniasis due to Leishmania donovani. The molecular …

The current standard treatment for leishmaniasis has remained the same for over 100 years,
despite inducing several adverse effects and increasing cases of resistance. In this study we …

In this study, we combined electron paramagnetic resonance (EPR) spectroscopy with an
analysis of biophysical cellular parameters to study the mechanisms underlying the in vitro …

The interaction of miltefosine with amphotericin B, sodium stibogluconate, paromomycin,
and sitamaquine was assessed in vitro and additionally for the first three combinations in …

Leishmaniasis, a major health problem worldwide, has a limited arsenal of drugs for its
control. The appearance of resistance to first-and second-line anti-leishmanial drugs …

Abstract Miltefosine (MIL), an alkylphospholipid, is the first orally administrable anti-
leishmanial drug. But due to its long half-life, miltefosine is highly vulnerable for resistance …