Control of selective mRNA translation in neuronal subcellular compartments in health and disease
R Cagnetta, JG Flanagan… - Journal of …, 2023 - Soc Neuroscience
In multiple cell types, mRNAs are transported to subcellular compartments, where local
translation enables rapid, spatially localized, and specific responses to external stimuli …
translation enables rapid, spatially localized, and specific responses to external stimuli …
Axonal mRNA localization and translation: local events with broad roles
L Li, J Yu, SJ Ji - Cellular and Molecular Life Sciences, 2021 - Springer
Messenger RNA (mRNA) can be transported and targeted to different subcellular
compartments and locally translated. Local translation is an evolutionally conserved …
compartments and locally translated. Local translation is an evolutionally conserved …
Local translation in nervous system pathologies
M Gamarra, A De la Cruz, M Blanco-Urrejola… - Frontiers in Integrative …, 2021 - frontiersin.org
Dendrites and axons can extend dozens to hundreds of centimeters away from the cell body
so that a single neuron can sense and respond to thousands of stimuli. Thus, for an accurate …
so that a single neuron can sense and respond to thousands of stimuli. Thus, for an accurate …
mRNA transport & local translation in neurons
C Glock, M Heumüller, EM Schuman - Current opinion in neurobiology, 2017 - Elsevier
Highlights•∼ 2550 mRNA species are localized in dendrites and/or axons.•The alternative
usage of 3′ UTR isoforms dictates the fate of an mRNA molecule.•Novel multiplexed FISH …
usage of 3′ UTR isoforms dictates the fate of an mRNA molecule.•Novel multiplexed FISH …
The differences in local translatome across distinct neuron types is mediated by both baseline cellular differences and post-transcriptional mechanisms
Local translation in neurites is a phenomenon that enhances the spatial segregation of
proteins and their functions away from the cell body, yet it is unclear how local translation …
proteins and their functions away from the cell body, yet it is unclear how local translation …
Spatially restricting gene expression by local translation at synapses
DO Wang, KC Martin, RS Zukin - Trends in neurosciences, 2010 - cell.com
mRNA localization and regulated translation provide a means of spatially restricting gene
expression within each of the thousands of subcellular compartments made by a neuron …
expression within each of the thousands of subcellular compartments made by a neuron …
mRNA trafficking and local translation: the Yin and Yang of regulating mRNA localization in neurons
JR Sinnamon, K Czaplinski - Acta Biochim Biophys Sin, 2011 - academic.oup.com
Localized translation and the requisite trafficking of the mRNA template play significant roles
in the nervous system including the establishment of dendrites and axons, axon path …
in the nervous system including the establishment of dendrites and axons, axon path …
Meet the players: local translation at the synapse
SM Fernandez-Moya, KE Bauer… - Frontiers in molecular …, 2014 - frontiersin.org
It is widely believed that activity-dependent synaptic plasticity is the basis for learning and
memory. Both processes are dependent on new protein synthesis at the synapse. Here, we …
memory. Both processes are dependent on new protein synthesis at the synapse. Here, we …
Translational control in brain pathologies: biological significance and therapeutic opportunities
Messenger RNA (mRNA) translation is the terminal step in protein synthesis, providing a
crucial regulatory checkpoint for this process. Translational control allows specific cell types …
crucial regulatory checkpoint for this process. Translational control allows specific cell types …
Axonal mRNA localization and local protein synthesis in nervous system assembly, maintenance and repair
Abstract mRNAs can be targeted to specific neuronal subcellular domains, which enables
rapid changes in the local proteome through local translation. This mRNA-based …
rapid changes in the local proteome through local translation. This mRNA-based …