The human transcriptome comprises> 80000 protein-coding transcripts and the estimated
number of proteins synthesized from these transcripts is in the range of 250000 to 1 million …

Alternative splicing, polyadenylation of pre-messenger RNA molecules and differential
promoter usage can produce a variety of transcript isoforms whose respective expression …

High-throughput RNA sequencing (RNA-seq) has revealed an enormous complexity of
alternative splicing (AS) across diverse cell and tissue types. However, it is currently …

The human transcriptome is so large, diverse, and dynamic that, even after a decade of
investigation by RNA sequencing (RNA-seq), we have yet to resolve its true dimensions …

Alternative splicing represents an important level of the regulation of gene function in
eukaryotic organisms. It plays a critical role in virtually every biological process within an …

Alternative RNA processing mechanisms, including alternative splicing and alternative
polyadenylation, are increasingly recognized as important regulators of gene expression …

Alternative pre–messenger RNA splicing influences development, physiology and disease,
but its regulation in humans is not well understood, partially because of the limited scale at …

Alternative splicing is commonly believed to be a major source of cellular protein diversity.
However, although many thousands of alternatively spliced transcripts are routinely detected …

Alternative splicing of mRNA precursors allows the synthesis of multiple mRNAs from a
single primary transcript, significantly expanding the information content and regulatory …

Genome-wide analyses of alternative splicing have established its nearly ubiquitous role in
gene regulation in many organisms. Genome sequencing and comparative genomics have …