Heterogeneity in human hippocampal CaMKII transcripts reveals allosteric hub-dependent regulation
R Sloutsky, N Dziedzic, MJ Dunn, RM Bates… - Science …, 2020 - science.org
Calcium/calmodulin-dependent protein kinase II (CaMKII) plays a central role in Ca2+
signaling throughout the body. In the hippocampus, CaMKII is required for learning and …
signaling throughout the body. In the hippocampus, CaMKII is required for learning and …
Quantitative proteomics analysis of CaMKII phosphorylation and the CaMKII interactome in the mouse forebrain
AJ Baucum, BC Shonesy, KL Rose… - ACS chemical …, 2015 - ACS Publications
Ca2+/calmodulin-dependent protein kinase IIα (CaMKIIα) autophosphorylation at Thr286
and Thr305/Thr306 regulates kinase activity and modulates subcellular targeting and is …
and Thr305/Thr306 regulates kinase activity and modulates subcellular targeting and is …
[HTML][HTML] CaMKII: claiming center stage in postsynaptic function and organization
JW Hell - Neuron, 2014 - cell.com
While CaMKII has long been known to be essential for synaptic plasticity and learning,
recent work points to new dimensions of CaMKII function in the nervous system, revealing …
recent work points to new dimensions of CaMKII function in the nervous system, revealing …
Functional implications of CaMKII alternative splicing
R Sloutsky, MM Stratton - European Journal of Neuroscience, 2021 - Wiley Online Library
Abstract Ca2+/calmodulin‐dependent protein kinase II (CaMKII) is known to be a crucial
regulator in the post‐synapse during long‐term potentiation. This important protein has been …
regulator in the post‐synapse during long‐term potentiation. This important protein has been …
βCaMKII plays a nonenzymatic role in hippocampal synaptic plasticity and learning by targeting αCaMKII to synapses
NZ Borgesius, GM van Woerden… - Journal of …, 2011 - Soc Neuroscience
The calcium/calmodulin-dependent kinase type II (CaMKII) holoenzyme of the forebrain
predominantly consists of heteromeric complexes of the αCaMKII and βCaMKII isoforms …
predominantly consists of heteromeric complexes of the αCaMKII and βCaMKII isoforms …
[HTML][HTML] Alternative splicing modulates the frequency-dependent response of CaMKII to Ca2+ oscillations
KU Bayer, P De Koninck, H Schulman - The EMBO journal, 2002 - embopress.org
Ca 2+ oscillations are required in various signal trans duction pathways, and contain
information both in their amplitude and frequency. Remarkably, the Ca 2+/calmodulin (CaM) …
information both in their amplitude and frequency. Remarkably, the Ca 2+/calmodulin (CaM) …
Emerging role of CaMKII in neuropsychiatric disease
AJ Robison - Trends in neurosciences, 2014 - cell.com
Although it has been known for decades that hippocampal calcium/calmodulin (CaM)-
dependent protein kinase II (CaMKII) plays an essential role in learning and memory …
dependent protein kinase II (CaMKII) plays an essential role in learning and memory …
Prominent expression and activity‐dependent nuclear translocation of Ca2+/calmodulin‐dependent protein kinase Iδ in hippocampal neurons
H Sakagami, A Kamata, H Nishimura… - European Journal of …, 2005 - Wiley Online Library
Abstract Multifunctional Ca2+/calmodulin‐dependent protein kinases (CaMKs) including
CaMKI, II and IV, are thought to regulate a variety of neuronal functions. Unlike CaMKII …
CaMKI, II and IV, are thought to regulate a variety of neuronal functions. Unlike CaMKII …
[HTML][HTML] Analysis of the CaMKIIα and β splice-variant distribution among brain regions reveals isoform-specific differences in holoenzyme formation
SG Cook, AM Bourke, H O'Leary, V Zaegel, E Lasda… - Scientific reports, 2018 - nature.com
Four CaMKII isoforms are encoded by distinct genes, and alternative splicing within the
variable linker-region generates additional diversity. The α and β isoforms are largely brain …
variable linker-region generates additional diversity. The α and β isoforms are largely brain …
[HTML][HTML] Structure of the CaMKIIδ/calmodulin complex reveals the molecular mechanism of CaMKII kinase activation
Long-term potentiation (LTP), a long-lasting enhancement in communication between
neurons, is considered to be the major cellular mechanism underlying learning and memory …
neurons, is considered to be the major cellular mechanism underlying learning and memory …