Heterogeneity in human hippocampal CaMKII transcripts reveals allosteric hub-dependent regulation

R Sloutsky, N Dziedzic, MJ Dunn, RM Bates… - Science …, 2020 - science.org
Calcium/calmodulin-dependent protein kinase II (CaMKII) plays a central role in Ca2+
signaling throughout the body. In the hippocampus, CaMKII is required for learning and …

Quantitative proteomics analysis of CaMKII phosphorylation and the CaMKII interactome in the mouse forebrain

AJ Baucum, BC Shonesy, KL Rose… - ACS chemical …, 2015 - ACS Publications
Ca2+/calmodulin-dependent protein kinase IIα (CaMKIIα) autophosphorylation at Thr286
and Thr305/Thr306 regulates kinase activity and modulates subcellular targeting and is …

[HTML][HTML] CaMKII: claiming center stage in postsynaptic function and organization

JW Hell - Neuron, 2014 - cell.com
While CaMKII has long been known to be essential for synaptic plasticity and learning,
recent work points to new dimensions of CaMKII function in the nervous system, revealing …

Functional implications of CaMKII alternative splicing

R Sloutsky, MM Stratton - European Journal of Neuroscience, 2021 - Wiley Online Library
Abstract Ca2+/calmodulin‐dependent protein kinase II (CaMKII) is known to be a crucial
regulator in the post‐synapse during long‐term potentiation. This important protein has been …

βCaMKII plays a nonenzymatic role in hippocampal synaptic plasticity and learning by targeting αCaMKII to synapses

NZ Borgesius, GM van Woerden… - Journal of …, 2011 - Soc Neuroscience
The calcium/calmodulin-dependent kinase type II (CaMKII) holoenzyme of the forebrain
predominantly consists of heteromeric complexes of the αCaMKII and βCaMKII isoforms …

[HTML][HTML] Alternative splicing modulates the frequency-dependent response of CaMKII to Ca2+ oscillations

KU Bayer, P De Koninck, H Schulman - The EMBO journal, 2002 - embopress.org
Ca 2+ oscillations are required in various signal trans duction pathways, and contain
information both in their amplitude and frequency. Remarkably, the Ca 2+/calmodulin (CaM) …

Emerging role of CaMKII in neuropsychiatric disease

AJ Robison - Trends in neurosciences, 2014 - cell.com
Although it has been known for decades that hippocampal calcium/calmodulin (CaM)-
dependent protein kinase II (CaMKII) plays an essential role in learning and memory …

Prominent expression and activity‐dependent nuclear translocation of Ca2+/calmodulin‐dependent protein kinase Iδ in hippocampal neurons

H Sakagami, A Kamata, H Nishimura… - European Journal of …, 2005 - Wiley Online Library
Abstract Multifunctional Ca2+/calmodulin‐dependent protein kinases (CaMKs) including
CaMKI, II and IV, are thought to regulate a variety of neuronal functions. Unlike CaMKII …

[HTML][HTML] Analysis of the CaMKIIα and β splice-variant distribution among brain regions reveals isoform-specific differences in holoenzyme formation

SG Cook, AM Bourke, H O'Leary, V Zaegel, E Lasda… - Scientific reports, 2018 - nature.com
Four CaMKII isoforms are encoded by distinct genes, and alternative splicing within the
variable linker-region generates additional diversity. The α and β isoforms are largely brain …

[HTML][HTML] Structure of the CaMKIIδ/calmodulin complex reveals the molecular mechanism of CaMKII kinase activation

P Rellos, ACW Pike, FH Niesen, E Salah, WH Lee… - PLoS …, 2010 - journals.plos.org
Long-term potentiation (LTP), a long-lasting enhancement in communication between
neurons, is considered to be the major cellular mechanism underlying learning and memory …