Prolactin (PRL) has recently been demonstrated to elicit female-selective nociceptor
sensitization and increase pain-like behaviors in female animals. Here we report the …

Pain is more prevalent in women for reasons that remain unclear. We have identified a
mechanism of injury-free nociceptor sensitization and opioid-induced hyperalgesia (OIH) …

Many clinical and preclinical studies report an increased prevalence and severity of chronic
pain among females. Here, we identify a sex-hormone-controlled target and mechanism that …

The prolactin receptor (PRLR) has been implicated in a variety of physiological processes
(lactation, reproduction) and diseases (breast cancer, autoimmune diseases). Prolactin …

Women experience many pain conditions more frequently when compared with men, but the
biological mechanisms underlying sex differences in pain remain poorly understood. In …

Pain development and resolution patterns in many diseases are sex-dependent. This study
aimed to develop pain models with sex-dependent resolution trajectories, and identify …

Introduction: Prolactin (PRL) signaling has emerged as a relevant target in breast and
prostate cancers. This has encouraged various laboratories to develop compounds targeting …

To provide new tools for in vitro and in vivo prolactin (PRL) research, novel protocols for
large-scale preparation of untagged human PRL (hPRL), a hPRL antagonist (del 1–9 …

Many clinical and preclinical studies report higher prevalence and severity of chronic pain in
females. We used hyperalgesic priming with interleukin 6 (IL-6) priming and PGE 2 as a …

Prolactin (PRL) regulates activity of nociceptors and causes hyperalgesia in pain conditions.
PRL enhances nociceptive responses by rapidly modulating channels in nociceptors. The …