Discovery and characterization of prolactin neutralizing monoclonal antibodies for the treatment of female-prevalent pain disorders
S Maciuba, GD Bowden, HJ Stratton, K Wisniewski… - MAbs, 2023 - Taylor & Francis
Prolactin (PRL) has recently been demonstrated to elicit female-selective nociceptor
sensitization and increase pain-like behaviors in female animals. Here we report the …
sensitization and increase pain-like behaviors in female animals. Here we report the …
The prolactin receptor long isoform regulates nociceptor sensitization and opioid-induced hyperalgesia selectively in females
Pain is more prevalent in women for reasons that remain unclear. We have identified a
mechanism of injury-free nociceptor sensitization and opioid-induced hyperalgesia (OIH) …
mechanism of injury-free nociceptor sensitization and opioid-induced hyperalgesia (OIH) …
Prolactin regulates pain responses via a female-selective nociceptor-specific mechanism
M Patil, S Belugin, J Mecklenburg, A Wangzhou… - IScience, 2019 - cell.com
Many clinical and preclinical studies report an increased prevalence and severity of chronic
pain among females. Here, we identify a sex-hormone-controlled target and mechanism that …
pain among females. Here, we identify a sex-hormone-controlled target and mechanism that …
A neutralizing prolactin receptor antibody whose in vivo application mimics the phenotype of female prolactin receptor-deficient mice
C Otto, A Särnefält, A Ljungars, S Wolf… - …, 2015 - academic.oup.com
The prolactin receptor (PRLR) has been implicated in a variety of physiological processes
(lactation, reproduction) and diseases (breast cancer, autoimmune diseases). Prolactin …
(lactation, reproduction) and diseases (breast cancer, autoimmune diseases). Prolactin …
An emerging role for prolactin in female-selective pain
Women experience many pain conditions more frequently when compared with men, but the
biological mechanisms underlying sex differences in pain remain poorly understood. In …
biological mechanisms underlying sex differences in pain remain poorly understood. In …
Sex-dependent pain trajectories induced by prolactin require an inflammatory response for pain resolution
J Mecklenburg, A Wangzhou, AH Hovhannisyan… - Brain, behavior, and …, 2022 - Elsevier
Pain development and resolution patterns in many diseases are sex-dependent. This study
aimed to develop pain models with sex-dependent resolution trajectories, and identify …
aimed to develop pain models with sex-dependent resolution trajectories, and identify …
The prolactin receptor as a therapeutic target in human diseases: browsing new potential indications
V Goffin, P Touraine - Expert opinion on therapeutic targets, 2015 - Taylor & Francis
Introduction: Prolactin (PRL) signaling has emerged as a relevant target in breast and
prostate cancers. This has encouraged various laboratories to develop compounds targeting …
prostate cancers. This has encouraged various laboratories to develop compounds targeting …
Novel reagents for human prolactin research: large-scale preparation and characterization of prolactin receptor extracellular domain, non-pegylated and pegylated …
E Ocłoń, G Solomon, Z Hayouka… - Protein Engineering …, 2018 - academic.oup.com
To provide new tools for in vitro and in vivo prolactin (PRL) research, novel protocols for
large-scale preparation of untagged human PRL (hPRL), a hPRL antagonist (del 1–9 …
large-scale preparation of untagged human PRL (hPRL), a hPRL antagonist (del 1–9 …
Neuroendocrine mechanisms governing sex differences in hyperalgesic priming involve prolactin receptor sensory neuron signaling
C Paige, PA Barba-Escobedo… - Journal of …, 2020 - Soc Neuroscience
Many clinical and preclinical studies report higher prevalence and severity of chronic pain in
females. We used hyperalgesic priming with interleukin 6 (IL-6) priming and PGE 2 as a …
females. We used hyperalgesic priming with interleukin 6 (IL-6) priming and PGE 2 as a …
Mechanisms of transient signaling via short and long prolactin receptor isoforms in female and male sensory neurons
S Belugin, AR Diogenes, MJ Patil, E Ginsburg… - Journal of Biological …, 2013 - ASBMB
Prolactin (PRL) regulates activity of nociceptors and causes hyperalgesia in pain conditions.
PRL enhances nociceptive responses by rapidly modulating channels in nociceptors. The …
PRL enhances nociceptive responses by rapidly modulating channels in nociceptors. The …