Immune surveillance by cytotoxic lymphocytes against cancer has been postulated for
decades, but direct evidence for the role of cytotoxic lymphocytes in protecting against …

Perforin (pfp) and interferon-γ (IFN-γ) together in C57BL/6 (B6) and BALB/c mouse strains
provided optimal protection in 3 separate tumor models controlled by innate immunity. Using …

Immune surveillance against tumors usually depends on T cell recognition of tumor antigens
presented by major histocompatibility complex (MHC) molecules, whereas MHC class I …

Perforin mutations have been demonstrated in a proportion of patients diagnosed with the
familial form of hemophagocytic lymphohistiocytosis (HLH). In the present study, we …

Studies with perforin-deficient mice have demonstrated that two independent mechanisms
account for T cell–mediated cytotoxicity: A main pathway is mediated by the secretion of the …

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Humans and mice with impaired perforin-dependent cytotoxic function may develop
excessive T-cell activation and the fatal disorder hemophagocytic lymphohistiocytosis (HLH) …

Cytotoxic lymphocytes (CLs) are the killer cells that destroy intracellular pathogen-infected
and transformed cells, predominantly through the cytotoxic granule-mediated death …

Recent progress has been made in discovering structure/function relationships of the
cytotoxic lymphocyte pore-forming protein—perforin—and its role in immune regulation …

Exocytosis of perforin, subsequent binding of perforin to the target cell membrane, and
formation of lytic pores form an important pathway involved in the induction of tumor cell …