Epidermal growth factor receptor (EGFR) is a vital intermediate in cell signaling pathway
including cell proliferation, angiogenesis, apoptosis, and metastatic spread and also having …

Epidermal Growth Factor Receptor (EGFR) is a transmembrane glycoprotein that constitutes
one of the four members of ErbB family of tyrosine kinase receptors. Activation of EGFR …

Tyrosine kinases are known to play a role in tumour growth and proliferation, and they have
become common drug targets. Tyrosine kinase inhibitors (TKIs) prohibit associated kinases …

Lung cancer is the leading cause of death worldwide. Current treatment modalities,
including chemotherapy, radiotherapy and surgery, provide only limited improvement in the …

The identification of molecular agents inhibiting specific functions in cancer cells
progression is considered as one of the most successful plans in cancer treatment. The …

Epidermal growth factor receptors (EGFRs) are a class of receptor tyrosine kinase that are
also called ErbB1 and HER1. EGFR tyrosine kinase activity inhibition is considered a …

Growth factor receptors and their ligands not only regulate normal cell processes but have
been also identified as key regulators of human cancer formation. The epidermal growth …

The epidermal growth factor receptor (EGFR) is part of a family of plasma membrane
receptor tyrosine kinases that control many important cellular functions, from cell growth and …

Cancer chemotherapy has entered a new era of molecularly targeted therapeutics, in which
structure based approaches are employed to create small molecule. This design has been …

Epidermal growth factor receptor (EGFR), also known as ErbB-1/HER-1, plays a key role in
the regulation of the cell proliferation, migration, differentiation, and survival. Since the …