[HTML][HTML] The role of Cryptococcus neoformans histone deacetylase genes in the response to antifungal drugs, epigenetic modulators and to photodynamic therapy …

K Ranjan, F Brandão, JAV Morais… - … of Photochemistry and …, 2021 - Elsevier
Cryptococcus is a globally distributed fungal pathogen that primarily afflicts
immunocompromised individuals. The therapeutic options are limited and include mostly …

Photodynamic therapy inhibits cell growth and enhances the histone deacetylase-mediated viability impairment in Cryptococcus spp. in vitro

JAV Morais, MC Rodrigues, FF Ferreira… - Photodiagnosis and …, 2020 - Elsevier
Cryptococcosis is a disseminated infection caused mainly by C. neoformans and C. gattii.
Limitations for the treatment involve the selection of isolates resistant to conventional …

Histone deacetylases inhibitors effects on Cryptococcus neoformans major virulence phenotypes

FAS Brandao, LS Derengowski, P Albuquerque… - Virulence, 2015 - Taylor & Francis
Cryptococcus neoformans undergoes phenotypical changes during host infection in order to
promote persistence and survival. Studies have demonstrated that such adaptations require …

Photodynamic inactivation of Candida albicans and Candida tropicalis with aluminum phthalocyanine chloride nanoemulsion

GB Rodrigues, GTP Brancini, MR Pinto, FL Primo… - Fungal Biology, 2020 - Elsevier
The in vitro susceptibilities of Candida albicans and Candida tropicalis to Antimicrobial
Photodynamic Treatment with aluminum phthalocyanine chloride in nanoemulsion …

In Vitro Photodynamic Inactivation of Cryptococcus neoformans Melanized Cells with Chloroaluminum Phthalocyanine Nanoemulsion

GB Rodrigues, FL Primo, AC Tedesco… - Photochemistry and …, 2012 - Wiley Online Library
The selection of fungi resistant to currently used fungicides and the emergence of new
pathogenic species make the development of alternative fungus‐control techniques highly …

Photosensitized inactivation of Acanthamoeba palestinensis in the cystic stage

S Ferro, O Coppellotti, G Roncucci… - Journal of applied …, 2006 - academic.oup.com
Aims: To develop alternative approaches for medical and environmental control of
pathogenic Acanthamoeba spp. by means of photodynamic treatment with a tetracationic Zn …

Histone deacetylases: targets for antifungal drug development

L Kmetzsch - Virulence, 2015 - Taylor & Francis
The interaction of pathogens and its hosts causes a drastic change in the transcriptional
landscape in both cells. Among the several mechanisms of gene regulation, transcriptional …

Histone Deacetylase Inhibitors Enhance Candida albicans Sensitivity to Azoles and Related Antifungals: Correlation with Reduction in CDR and ERG Upregulation

WL Smith, TD Edlind - Antimicrobial agents and chemotherapy, 2002 - Am Soc Microbiol
Histone acetylation and deacetylation play important roles in eukaryotic gene regulation.
Several histone deacetylase (HDA) inhibitors have been characterized, including trichostatin …

Antiproliferation and Antiencystation Effect of Class II Histone Deacetylase Inhibitors on Acanthamoeba castellanii

KB Chu, HA Lee, M Pflieger, F Fischer… - ACS Infectious …, 2022 - ACS Publications
Acanthamoeba is a ubiquitous and free-living protozoan pathogen responsible for causing
Acanthamoeba keratitis (AK), a severe corneal infection inflicting immense pain that can …

Consecutive treatments with photodynamic therapy and nystatin altered the expression of virulence and ergosterol biosynthesis genes of a fluconazole-resistant …

CC Jordao, MI Klein, JC Carmello, LM Dias… - Photodiagnosis and …, 2021 - Elsevier
This investigation assessed the effect of five consecutive daily topical treatments of
antimicrobial photodynamic therapy (aPDT), nystatin (NYS), and an association of …