Protective properties of neural extracellular matrix

A Suttkus, M Morawski, T Arendt - Molecular neurobiology, 2016 - Springer
The extracellular matrix (ECM) of the central nervous system (CNS) occupies a large part of
the neural tissue. It serves a variety of functions ranging from support of cell migration and …

Pathophysiology of the brain extracellular matrix: a new target for remyelination

LW Lau, R Cua, MB Keough… - Nature Reviews …, 2013 - nature.com
The extracellular matrix (ECM) occupies a notable proportion of the CNS and contributes to
its normal physiology. Alterations to the ECM occur after neural injury (for example, in …

[HTML][HTML] Perineuronal nets and CNS plasticity and repair

D Carulli, JCF Kwok, T Pizzorusso - Neural Plasticity, 2016 - hindawi.com
The extracellular matrix (ECM) of the nervous system regulates numerous events during
development, from neurogenesis and gliogenesis to circuitry formation, as well as in …

Perineuronal nets and their role in synaptic homeostasis

M Bosiacki, M Gąssowska-Dobrowolska… - International journal of …, 2019 - mdpi.com
Extracellular matrix (ECM) molecules that are released by neurons and glial cells form
perineuronal nets (PNNs) and modulate many neuronal and glial functions. PNNs, whose …

Chondroitin sulfate proteoglycans: Key modulators in the developing and pathologic central nervous system

SM Dyck, S Karimi-Abdolrezaee - Experimental neurology, 2015 - Elsevier
Abstract Chondroitin Sulfate Proteoglycans (CSPGs) are a major component of the
extracellular matrix in the central nervous system (CNS) and play critical role in the …

Mechanisms for modulation of neural plasticity and axon regeneration by chondroitin sulphate

S Miyata, H Kitagawa - The journal of biochemistry, 2015 - academic.oup.com
Chondroitin sulphate proteoglycans (CSPGs), consisting of core proteins linked to one or
more chondroitin sulphate (CS) chains, are major extracellular matrix (ECM) components of …

Targeting the neural extracellular matrix in neurological disorders

S Soleman, MA Filippov, A Dityatev, JW Fawcett - Neuroscience, 2013 - Elsevier
The extracellular matrix (ECM) is known to regulate important processes in neuronal cell
development, activity and growth. It is associated with the structural stabilization of neuronal …

[HTML][HTML] A glial perspective on the extracellular matrix and perineuronal net remodeling in the central nervous system

BP Tewari, L Chaunsali, CE Prim… - Frontiers in cellular …, 2022 - frontiersin.org
A structural scaffold embedding brain cells and vasculature is known as extracellular matrix
(ECM). The physical appearance of ECM in the central nervous system (CNS) ranges from a …

Looking inside the matrix: perineuronal nets in plasticity, maladaptive plasticity and neurological disorders

C De Luca, M Papa - Neurochemical Research, 2016 - Springer
The integrity of the central nervous system (CNS) matrix is crucial for its proper function.
Loss of the lattice-like structure compromise synaptic stability and can lead to the disruption …

Neural ECM in regeneration and rehabilitation

S Yang, JCF Kwok, JW Fawcett - Progress in Brain Research, 2014 - Elsevier
Neural extracellular matrix (ECM) is different from the normal ECM in other organs in that it
has low fibrous protein content and high carbohydrate content. One of the key carbohydrate …