Type 1 diabetes mellitus (T1DM) is a chronic autoimmune disease with a strong
inflammatory component. The latest studies indicate that innate immunity and inflammatory …

Type 1 diabetes (T1D) is a chronic autoimmune disease in which autoreactive T‐cells and
inflammation cause severe loss of pancreatic beta cells. Insulitis, the pathologic hallmark of …

The escalating epidemic of obesity has driven the prevalence of both type 1 and 2 diabetes
mellitus to historically high levels. Chronic low-grade inflammation, which is present in both …

Onset of Type 2 diabetes occurs when the pancreatic β-cell fails to adapt to the increased
insulin demand caused by insulin resistance. Morphological and therapeutic intervention …

Insulin‐dependent diabetes mellitus (IDDM) is not a disease of unbridled destruction. The
autoimmune attack on pancreatic beta cells has two distinct stages–insulitis and diabetes …

Human type 1 diabetes (T1D) is considered to be an autoimmune disease, with CD8+ T-cell-
mediated cytotoxicity being directed against the insulin-producing beta cells, leading to a …

The histopathology of type 1 diabetes is defined by a decreased β-cell mass in association
with insulitis, a characteristic lymphocytic infiltration limited to the islets of Langerhans and …

Correlation studies between cytokines expressed in islets and autoimmune diabetes
development in NOD mice and BB rats have demonstrated that β‐cell destructive insulitis is …

Type 1 diabetes (T1D) results from a T cell–mediated destruction of pancreatic β-cells
following the infiltration of leukocytes (including CD8+, CD4+, and CD20+ cells) into and …

Type one diabetes (T1D) is a complex T cell-mediated autoimmune disease, the defining
feature of which is the destruction of the insulin-secreting beta-(β)-cell. Both genetic and …