The bone marrow is a complex tissue in which heterogeneous populations of stromal cells
interact with hematopoietic cells to dynamically respond to organismal needs in defense …

Normal hematopoiesis is maintained by dynamic interactions between hematopoietic cells
and the bone marrow microenvironment. In hematological malignancies, there are …

Hematopoietic stem cells (HSCs) interact dynamically with an intricate network of cells in the
bone marrow (BM) microenvironment or niche. These interactions provide instructive cues …

The bone marrow microenvironment (BMM) is the 'domicile'of hematopoietic stem cells, as
well as of malignant processes that can develop there. Multiple and complex interactions …

Hematopoietic stem cell (HSC) proliferation, self-renewal, and trafficking are dependent, in
part, upon signals generated by stromal cells in the bone marrow. Stromal cells are …

The bone marrow microenvironment contains a heterogeneous population of stromal cells
organized into niches that support hematopoietic stem cells (HSCs) and other lineage …

Regulation of stem cells in adult tissues is a key determinant of how well an organism can
respond to the stresses of physiological challenge and disease. This is particularly true of …

Similar to their healthy counterpart, malignant hematopoietic stem cells in myeloid
malignancies, such as myeloproliferative neoplasms, myelodysplastic syndromes, and acute …

Dynamic interactions between leukaemic cells and cells of the bone marrow are a feature of
haematological malignancies. Two distinct microenvironmental niches in the bone marrow …

The interplay of cancer cells and surrounding stroma is critical in disease progression. This
is particularly evident in hematological malignancies that infiltrate the bone marrow and …