Efficacy of Azacitidine in autoimmune and inflammatory disorders associated with myelodysplastic syndromes and chronic myelomonocytic leukemia

JB Fraison, A Mekinian, E Grignano, JE Kahn, JB Arlet… - Leukemia research, 2016 - Elsevier
This retrospective study describes efficacy of Azacitidine on autoimmune disorders (AID)
associated with MDS/CMML in 22 patients. Response of AID to Azacitidine was observed in …

Systemic inflammatory and autoimmune manifestations associated with myelodysplastic syndromes and chronic myelomonocytic leukaemia: a French multicentre …

A Mekinian, E Grignano, T Braun, O Decaux… - …, 2016 - academic.oup.com
Objective. We describe myelodysplastic syndrome (MDS)–associated systemic inflammatory
and autoimmune diseases (SIADs), their treatments and outcomes and the impact of SIADs …

Myelodysplastic syndromes and autoimmune diseases—case series and review of literature

O Al Ustwani, LA Ford, SJN Sait, AMW Block… - Leukemia research, 2013 - Elsevier
Our objective was to recognize the association of autoimmune diseases (AD) in patients with
myelodysplastic syndromes (MDS) and understand how this association could affect …

Rapid loss of response after withdrawal of treatment with azacitidine: a case series in patients with higher‐risk myelodysplastic syndromes or chronic myelomonocytic …

MT Voso, M Breccia, M Lunghi, A Poloni… - European journal of …, 2013 - Wiley Online Library
In patients with myelodysplastic syndromes (MDS), the likelihood of having a sustained
response to azacitidine is increased by maximizing treatment duration. This is important as …

Prolonged responses in patients with MDS and CMML treated with azacitidine and etanercept

BL Scott, A Ramakrishnan, B Storer… - British journal of …, 2010 - Wiley Online Library
Combination therapy with azacitidine and etanercept was hypothesized to lead to improved
responses in myelodysplastic syndrome (MDS) patients. Thirty‐two patients with …

Randomized controlled trial of azacitidine in patients with the myelodysplastic syndrome: a study of the cancer and leukemia group B

LR Silverman, EP Demakos, BL Peterson… - Journal of Clinical …, 2002 - ascopubs.org
PURPOSE: Patients with high-risk myelodysplastic syndrome (MDS) have high mortality
from bone marrow failure or transformation to acute leukemia. Supportive care is standard …

Autoimmune manifestations associated with myelodysplastic syndromes

E Grignano, V Jachiet, P Fenaux, L Ades, O Fain… - Annals of …, 2018 - Springer
Autoimmune disorders (ADs) are encountered in 10 to 20% of patients with myelodysplastic
syndromes (MDS). Available data suggest that ADs concern more often younger patients …

Further analysis of trials with azacitidine in patients with myelodysplastic syndrome: studies 8421, 8921, and 9221 by the Cancer and Leukemia Group B

LR Silverman, DR McKenzie, BL Peterson… - Journal of Clinical …, 2006 - ascopubs.org
Purpose Within the last two decades, a new understanding of the biology of myelodysplastic
syndrome (MDS) has developed. With this understanding, new classification systems, such …

Activity of azacitidine in chronic myelomonocytic leukemia

R Costa, H Abdulhaq, B Haq, RK Shadduck, J Latsko… - Cancer, 2011 - Wiley Online Library
BACKGROUND: Hypomethylating drugs are useful in the management of myelodysplastic
syndrome (MDS). Two of these drugs, azacitidine and decitabine, have received FDA …

Azacitidine in the management of patients with myelodysplastic syndromes

C Khan, N Pathe, S Fazal, J Lister… - Therapeutic …, 2012 - journals.sagepub.com
Myelodysplastic syndromes (MDS) are a heterogeneous group of clonal hematopoeitic
disorders characterized by ineffective hematopoiesis and potential transformation to acute …