Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci
We simultaneously investigated the genetic landscape of ankylosing spondylitis, Crohn's
disease, psoriasis, primary sclerosing cholangitis and ulcerative colitis to investigate …
disease, psoriasis, primary sclerosing cholangitis and ulcerative colitis to investigate …
Genome-wide association study of primary sclerosing cholangitis identifies new risk loci and quantifies the genetic relationship with inflammatory bowel disease
Primary sclerosing cholangitis (PSC) is a rare progressive disorder leading to bile duct
destruction;∼ 75% of patients have comorbid inflammatory bowel disease (IBD). We …
destruction;∼ 75% of patients have comorbid inflammatory bowel disease (IBD). We …
Dense genotyping of immune-related disease regions identifies nine new risk loci for primary sclerosing cholangitis
Primary sclerosing cholangitis (PSC) is a severe liver disease of unknown etiology leading
to fibrotic destruction of the bile ducts and ultimately to the need for liver transplantation,,. We …
to fibrotic destruction of the bile ducts and ultimately to the need for liver transplantation,,. We …
Fine-mapping inflammatory bowel disease loci to single-variant resolution
Inflammatory bowel diseases are chronic gastrointestinal inflammatory disorders that affect
millions of people worldwide. Genome-wide association studies have identified 200 …
millions of people worldwide. Genome-wide association studies have identified 200 …
Genetic mapping across autoimmune diseases reveals shared associations and mechanisms
MR Lincoln, N Connally, PP Axisa, C Gasperi… - Nature Genetics, 2024 - nature.com
Autoimmune and inflammatory diseases are polygenic disorders of the immune system.
Many genomic loci harbor risk alleles for several diseases, but the limited resolution of …
Many genomic loci harbor risk alleles for several diseases, but the limited resolution of …
Common variants at five new loci associated with early-onset inflammatory bowel disease
The inflammatory bowel diseases (IBD) Crohn's disease and ulcerative colitis are common
causes of morbidity in children and young adults in the western world. Here we report the …
causes of morbidity in children and young adults in the western world. Here we report the …
Genome-wide association analysis in primary sclerosing cholangitis identifies two non-HLA susceptibility loci
E Melum, A Franke, C Schramm, TJ Weismüller… - Nature …, 2011 - nature.com
Primary sclerosing cholangitis (PSC) is a chronic bile duct disease affecting 2.4–7.5% of
individuals with inflammatory bowel disease. We performed a genome-wide association …
individuals with inflammatory bowel disease. We performed a genome-wide association …
Recent insights into the genetics of inflammatory bowel disease
JH Cho, SR Brant - Gastroenterology, 2011 - Elsevier
Inflammatory bowel diseases (IBDs) are complex, multifactorial disorders that comprise
Crohn's disease (CD) and ulcerative colitis (UC). Genome-wide association studies have …
Crohn's disease (CD) and ulcerative colitis (UC). Genome-wide association studies have …
Genome-wide association identifies multiple ulcerative colitis susceptibility loci
DPB McGovern, A Gardet, L Törkvist, P Goyette… - Nature …, 2010 - nature.com
Ulcerative colitis is a chronic, relapsing inflammatory condition of the gastrointestinal tract
with a complex genetic and environmental etiology. In an effort to identify genetic variation …
with a complex genetic and environmental etiology. In an effort to identify genetic variation …
[HTML][HTML] Genetics of inflammatory bowel disease from multifactorial to monogenic forms
AM Bianco, M Girardelli… - World journal of …, 2015 - ncbi.nlm.nih.gov
Inflammatory bowel disease (IBD) is a group of chronic multifactorial disorders. According to
a recent study, the number of IBD association loci is increased to 201, of which 37 and 27 …
a recent study, the number of IBD association loci is increased to 201, of which 37 and 27 …