Cell death can be classified into two primary categories: accidental cell death and regulated
cell death (RCD). Within RCD, there are distinct apoptotic and non-apoptotic cell death …

Given the problems with malignant cancer cells showing innate and acquired resistance to
apoptosis, we need alternative means to induce cell death in cancer. Paraptosis is a type of …

Programmed cell death (PCD) is the universal process that maintains cellular homeostasis
and regulates all living systems' development, health and disease. Out of all, apoptosis is …

Standard anti-cancer therapies promote tumor growth suppression mainly via induction of
apoptosis. However, in most cases cancer cells acquire the ability to escape apoptotic cell …

Due to the sustained proliferative potential of cancer cells, inducing cell death is a potential
strategy for cancer therapy. Paraptosis is a mode of cell death characterized by endoplasmic …

Cancerous growth is one of the most difficult diseases to target as there is no one clear
cause, and targeting only one pathway does not generally produce quantifiable …

Apoptosis is a cell suicide program that plays a critical role in development and tissue
homeostasis. The ability of cancer cells to evade this programmed cell death (PCD) is a …

Killing of tumor cells by anticancer therapies commonly used in the treatment of cancer, eg
chemotherapy, γ-irradiation, immunotherapy or suicide gene therapy, is predominantly …

Programmed cell death or apoptosis is of fundamental importance to cancer as it both limits
tumorigenesis and is also triggered by many cancer chemotherapeutics. Many oncogenes …

This chapter describes a distinct type of cell death called paraptosis. Paraptosis is a caspase
independent programmed cell death with similarities to apoptosis and necrosis. It is …