New Antiproliferative Triflavanone from Thymelaea hirsuta—Isolation, Structure Elucidation and Molecular Docking Studies

SS Elhady, RFA Abdelhameed, MM El-Ayouty… - Molecules, 2021 - mdpi.com
In this study isolates from Thymelaea hirsuta, a wild plant from the Sinai Peninsula of Egypt,
were identified and their selective cytotoxicity levels were evaluated. Phytochemical …

[HTML][HTML] Design, synthesis and biological evaluation of valepotriate derivatives as novel antitumor agents

B Zhang, R Guo, Y Hu, X Dong, N Lin, X Dai, H Wu… - Rsc Advances, 2017 - pubs.rsc.org
Natural products remain the largest resources of lead compounds that can be used to
develop novel anticancer drug candidates. Based on deacetylisovaltratum, a natural product …

Crystal Structure Elucidation and Anticancer Studies of (-)-Pseudosemiglabrin: A Flavanone Isolated from the Aerial Parts of Tephrosia apollinea

LE Ahmed Hassan, MB Khadeer Ahamed… - PLoS …, 2014 - journals.plos.org
Tephrosia apollinea is a perennial shrublet widely distributed in Africa and is known to have
medicinal properties. The current study describes the bio-assay (cytotoxicity) guided …

Novel Bis-spiro-labdane type Diterpenes from Leonotis nepetifolia: Isolation, Semi-synthesis, and Evaluation of their Cytotoxic Activities

BV Rao, S Swain, B Siva, TS Priya, VJ Alli… - Journal of Molecular …, 2024 - Elsevier
Traditional medicinal plants offer huge opportunities to discover novel therapeutics against
many diseases. Investigation into the chemical diversity of the traditional medicinal plant …

Synthesis, characterization, and anticancer activity of new N, N′-Diarylthiourea derivative against breast cancer cells

MA El-Atawy, MS Alsubaie, ML Alazmi, EA Hamed… - Molecules, 2023 - mdpi.com
The goal of the current study was to prepare two new homologous series of N, N′-
diarylurea and N, N′-diarylthiourea derivatives to investigate the therapeutic effects of …

Potential anti-hepatocellular carcinoma properties and mechanisms of action of clerodane diterpenes isolated from Polyalthia longifolia seeds

VB Tatipamula, CV Thonangi, TC Dakal, GS Vedula… - Scientific Reports, 2022 - nature.com
Diterpenes are secondary metabolites that have attracted much attention due to their
potential biological activities including anti-cancer potential. The aim of the current study is …

Two new flavonoids and anticancer activity of Hymenosporum flavum: in vitro and molecular docking studies

RF Taher, AA Al-Karmalawy… - Journal of …, 2021 - herbmedpharmacol.com
Abstract Introduction: Hymenosporum flavum (Hook.) F. Muell. is the sole species within the
genus Hymenosporum is known for its antimicrobial activity. The current study aims to …

Chamaejasmenin E from Stellera chamaejasme induces apoptosis of hepatocellular carcinoma cells by targeting c-Met in vitro and in vivo

XQ Yu, QL Yan, S Shen, ZY Cheng, XX Huang… - Bioorganic …, 2022 - Elsevier
Hepatocellular carcinoma (HCC), the most prevalent liver cancer, is considered one of the
most lethal malignancies with a dismal outcome. There is an urgent need to find novel …

Anti-proliferative activity of Labdane Diterpenes isolated from Polyalthia cerasoides and their molecular interaction studies

RY Siddappa, SJ Aditya Rao, BM Usha… - Current Drug …, 2022 - ingentaconnect.com
Background: Polyalthia cerasoides is well known for its therapeutic effects and is extensively
used by the tribal people of South India and Africa to treat infertility, toothache, inflammation …

Assessment of Cytotoxic/Antitumour Potential and in silico Study of Salazinic Acid Isolated from Parmotrema concurrens

MA da Conceição de Lira, MM da Silva… - Anti-Cancer Agents …, 2023 - ingentaconnect.com
Introduction: Despite numerous scientific advances, cancer continues to be one of the main
causes of death in the world. This situation has driven the search for promising molecules …