Apathy and anhedonia are common syndromes of motivation that are associated with a wide
range of brain disorders and have no established therapies. Research using animal models …

Apathy is a debilitating syndrome associated with many neurological disorders, including
several common neurodegenerative diseases such as Parkinson's disease and Alzheimer's …

Disorders of diminished motivation, such as apathy, are common and prevalent across a
wide range of medical conditions, including Parkinson's disease, Alzheimer's dementia …

The past few decades have seen growing interest in the neuropsychiatric syndrome of
apathy, conceptualised as a loss of motivation manifesting as a reduction of goal-directed …

Motivation deficits, such as apathy, are pervasive in both neurological and psychiatric
diseases. Even when they are not the core symptom, they reduce quality of life, compromise …

Apathy is a common but poorly understood condition with a wide societal impact observed in
several brain disorders as well as, to some extent, in the normal population. Hence the need …

Anhedonia, the lack of pleasure, has been shown to be a critical feature of a range of
psychiatric disorders. Yet, it is currently measured primarily through subjective self-reports …

Effort-based decision-making is a cognitive process crucial to normal motivated behaviour.
Apathy is a common and disabling complication of Parkinson's disease, but its aetiology …

Anhedonia, or loss of interest or pleasure in usual activities, is characteristic of depression,
some types of anxiety, as well as substance abuse and schizophrenia. Anhedonia is a …

Work in animal and human neuroscience has identified neural regions forming a network
involved in the production of motivated, goal-directed behaviour. In particular, the nucleus …