[HTML][HTML] Tryptophan metabolism: a link between the gut microbiota and brain

K Gao, C Mu, A Farzi, W Zhu - Advances in Nutrition, 2020 - Elsevier
The gut-brain axis (GBA) is a bilateral communication network between the gastrointestinal
(GI) tract and the central nervous system. The essential amino acid tryptophan contributes to …

Focus on the essentials: tryptophan metabolism and the microbiome-gut-brain axis

CE Gheorghe, JA Martin, FV Manriquez… - Current opinion in …, 2019 - Elsevier
The gut-brain axis is a bidirectional communication system between the central nervous
system and the gastrointestinal tract, in which serotonin (5-HT) functions as a key …

[HTML][HTML] Tryptophan metabolism and gut-brain homeostasis

W Roth, K Zadeh, R Vekariya, Y Ge… - International journal of …, 2021 - mdpi.com
Tryptophan is an essential amino acid critical for protein synthesis in humans that has
emerged as a key player in the microbiota-gut-brain axis. It is the only precursor for the …

[HTML][HTML] Gut microbiota regulation of tryptophan metabolism in health and disease

A Agus, J Planchais, H Sokol - Cell host & microbe, 2018 - cell.com
The gut microbiota is a crucial actor in human physiology. Many of these effects are
mediated by metabolites that are either produced by the microbes or derived from the …

Tryptophan metabolites along the microbiota-gut-brain axis: an interkingdom communication system influencing the gut in health and disease

A Bosi, D Banfi, M Bistoletti… - International Journal of …, 2020 - journals.sagepub.com
The 'microbiota-gut-brain axis' plays a fundamental role in maintaining host homeostasis,
and different immune, hormonal, and neuronal signals participate to this interkingdom …

Beneficial actions of microbiota‐derived tryptophan metabolites

JJ Galligan - Neurogastroenterology & Motility, 2018 - Wiley Online Library
Tryptophan is an important dietary amino acid and it is the precursor for 5‐
hydroxytryptamine synthesis in the nervous system and by enterochromaffin cells in the gut …

Kynurenine pathway metabolism and the microbiota-gut-brain axis

PJ Kennedy, JF Cryan, TG Dinan, G Clarke - Neuropharmacology, 2017 - Elsevier
It has become increasingly clear that the gut microbiota influences not only gastrointestinal
physiology but also central nervous system (CNS) function by modulating signalling …

[HTML][HTML] Microbial tryptophan metabolism tunes host immunity, metabolism, and extraintestinal disorders

M Liu, M Nieuwdorp, WM de Vos, E Rampanelli - Metabolites, 2022 - mdpi.com
The trillions of commensal microorganisms comprising the gut microbiota have received
growing attention owing to their impact on host physiology. Recent advances in our …

Serotonin, tryptophan metabolism and the brain-gut-microbiome axis

SM O'Mahony, G Clarke, YE Borre, TG Dinan… - Behavioural brain …, 2015 - Elsevier
The brain-gut axis is a bidirectional communication system between the central nervous
system and the gastrointestinal tract. Serotonin functions as a key neurotransmitter at both …

Host–microbiome interactions: the aryl hydrocarbon receptor as a critical node in tryptophan metabolites to brain signaling

N Ma, T He, LJ Johnston, X Ma - Gut microbes, 2020 - Taylor & Francis
Tryptophan (Trp) is not only a nutrient enhancer but also has systemic effects. Trp
metabolites signaling through the well-known aryl hydrocarbon receptor (AhR) constitute the …