Brain tumor demarcation using optical spectroscopy: an in vitro study

WC Lin, SA Toms, M Motamedi… - … of biomedical optics, 2000 - spiedigitallibrary.org
Optical spectroscopy for brain tumor demarcation was investigated in this study.
Fluorescence and diffuse reflectance spectra were measured from normal and tumorous …

Tumor demarcation using optical spectroscopy

WC Lin, A Mahadevan-Jansen, ED Jansen… - US Patent …, 2002 - Google Patents
Optical spectroscopy for brain tumor demarcation was investigated in this study.
Fluorescence and diffuse reflectance spectra were measured from normal and tumorous …

In Vivo Brain Tumor Demarcation Using Optical Spectroscopy¶

WC Lin, SA Toms, M Johnson… - Photochemistry and …, 2001 - Wiley Online Library
The applicability of optical spectroscopy for intraoperative detection of brain tumors/tumor
margins was investigated in a pilot clinical trial consisting of 26 brain tumor patients. The …

Diffuse reflectance spectroscopy for in vivo pediatric brain tumor detection

WC Lin, DI Sandberg, S Bhatia… - … of biomedical optics, 2010 - spiedigitallibrary.org
The concept of using diffuse reflectance spectroscopy to distinguish intraoperatively
between pediatric brain tumors and normal brain parenchyma at the edge of resection …

A probability-based spectroscopic diagnostic algorithm for simultaneous discrimination of brain tumor and tumor margins from normal brain tissue

SK Majumder, S Gebhart, MD Johnson… - Applied …, 2007 - opg.optica.org
This paper reports the development of a probability-based spectroscopic diagnostic
algorithm capable of simultaneously discriminating tumor core and tumor margins from …

In vitro determination of normal and neoplastic human brain tissue optical properties using inverse adding-doubling

SC Gebhart, WC Lin… - Physics in Medicine & …, 2006 - iopscience.iop.org
To complement a project towards the development of real-time optical biopsy for brain tissue
discrimination and surgical resection guidance, the optical properties of various brain …

Dual-modality optical biopsy of glioblastomas multiforme with diffuse reflectance and fluorescence: ex vivo retrieval of optical properties

VN Du Le, J Provias, N Murty… - … of biomedical optics, 2017 - spiedigitallibrary.org
Glioma itself accounts for 80% of all malignant primary brain tumors, and glioblastoma
multiforme (GBM) accounts for 55% of such tumors. Diffuse reflectance and fluorescence …

Intraoperative optical spectroscopy identifies infiltrating glioma margins with high sensitivity

SA Toms, WC Lin, RJ Weil, MD Johnson… - …, 2007 - journals.lww.com
OBJECTIVE: Adult gliomas have indistinct borders. As the ratio of neoplastic cells to normal
cells becomes lower, the ability to detect these cells diminishes. We describe a device …

Fluorescence spectroscopy to discriminate neoplastic human brain lesions: a study using the spectral intensity ratio and multivariate linear discriminant analysis

SS Nazeer, A Saraswathy, AK Gupta… - Laser …, 2014 - iopscience.iop.org
Fluorescence spectroscopy is an emerging tool used to differentiate normal and malignant
tissue based on the emission spectral profile from endogenous fluorophores. The goal of …

Optimum wavelength for the differentiation of brain tumor tissue using autofluorescence spectroscopy

A Saraswathy, RS Jayasree, KV Baiju… - … and Laser Surgery, 2009 - liebertpub.com
Objective: The role of autofluorescence spectroscopy in the detection and staging of benign
and malignant brain tumors is being investigated in this study, with an additional aim of …