Flavonoids on diabetic nephropathy: advances and therapeutic opportunities

Q Hu, C Qu, X Xiao, W Zhang, Y Jiang, Z Wu, D Song… - Chinese medicine, 2021 - Springer
With the advances in biomedical technologies, natural products have attracted substantial
public attention in the area of drug discovery. Flavonoids are a class of active natural …

[HTML][HTML] Kidney protection effects of dihydroquercetin on diabetic nephropathy through suppressing ROS and NLRP3 inflammasome

T Ding, S Wang, X Zhang, W Zai, J Fan, W Chen… - Phytomedicine, 2018 - Elsevier
Background Diabetic nephropathy (DN), the leading cause of end-stage renal disease, is
acknowledged as an independent risk factor for cardiovascular disease, which underlines …

The effect of quercetin on diabetic nephropathy (DN): a systematic review and meta-analysis of animal studies

T Hu, J Yue, Q Tang, KW Cheng, F Chen, M Peng… - Food & Function, 2022 - pubs.rsc.org
Quercetin, a flavonoid possessing numerous biological activities, is reported to improve
renal injury in diabetic animals. Here, the aim of this systematic review and meta-analysis is …

Protective effects of plant‐derived natural products on renal complications

H Yaribeygi, LE Simental‐Mendía… - Journal of cellular …, 2019 - Wiley Online Library
Diabetic nephropathy is the leading cause of renal failure worldwide. This debilitating
disorder has several underlying pathophysiologic mechanisms, and therefore a variety of …

Effective dose/duration of natural flavonoid quercetin for treatment of diabetic nephropathy: A systematic review and meta-analysis of rodent data

Z Li, H Deng, X Guo, S Yan, C Lu, Z Zhao, X Feng, Q Li… - Phytomedicine, 2022 - Elsevier
Background Given the challenges on diabetic nephropathy (DN) treatment, research has
been carried out progressively focusing on dietary nutrition and natural products as a novel …

Flavonoids in kidney health and disease

F Vargas, P Romecín, AI García-Guillén… - Frontiers in …, 2018 - frontiersin.org
This review summarizes the latest advances in knowledge on the effects of flavonoids on
renal function in health and disease. Flavonoids have antihypertensive, antidiabetic, and …

Plant flavonoids on oxidative stress-mediated kidney inflammation

S Alsawaf, F Alnuaimi, S Afzal, RM Thomas… - Biology, 2022 - mdpi.com
Simple Summary Increased stress is often observed in patients with kidney diseases,
contributing to renal injury progression. Flavonoids are naturally occurring plant compounds …

Bioactive phytochemicals that regulate the cellular processes involved in diabetic nephropathy

A Parveen, M Jin, SY Kim - Phytomedicine, 2018 - Elsevier
Background Owing to the multiple causative factors, the current advances in medication for
diabetic nephropathy (DN) do not appear to have improved therapies for patients …

Protective effects of luteolin on diabetic nephropathy in STZ‐induced diabetic rats

GG Wang, XH Lu, W Li, X Zhao… - … and Alternative Medicine, 2011 - Wiley Online Library
Diabetic nephropathy is a long‐term complication of diabetic mellitus. Many experimental
evidences suggest that persistent hyperglycaemia generates intracellular reactive oxygen …

Eriodictyol inhibits high glucose‐induced extracellular matrix accumulation, oxidative stress, and inflammation in human glomerular mesangial cells

J Bai, Y Wang, X Zhu, J Shi - Phytotherapy Research, 2019 - Wiley Online Library
Diabetic nephropathy (DN) is one of the major complications of diabetes mellitus. The
progression of DN has been found to be associated with high glucose (HG)‐induced …