This review provides the reader a concise overview of the majority of prodrug approaches
with the emphasis on the modern approaches to prodrug design. The chemical approach …

Introduction: The revolution in computational chemistry greatly impacted the drug design
and delivery fields, in general, and recently the utilization of the prodrug approach in …

In this chapter we attempt to present a novel prodrug approach which is based on enzyme
models that have been advocated to understand the mechanism by which enzymes catalyze …

The striking efficiency of enzyme catalysis has inspired many organic chemists to explore
enzyme mechanisms by studying certain intra molecular processes such as enzyme models …

When knowledge fails to provide answers to important questions such as how to improve the
bioavailability of vital medications,“Imagination is more important than knowledge,” as Albert …

Prodrugs, soft drugs, targeted drugs, and metabolites of drugs are common terms that are
used in the pharmaceutical field. The term “prodrug” was first introduced by Albert to signify …

Helps you choose the right computational tools and techniques to meet your drug design
goals Computational Drug Design covers all of the major computational drug design …

Due to the large variation of structural features of bitter tasting molecules, it is difficult to
generalize the molecular requirements for bitterness. Nevertheless, it was reported that a …

Prodrug Design: Perspectives, Approaches and Applications in Medicinal Chemistry
provides a focused overview of this critical area of drug discovery, as that continuous …

DFT calculation results for intramolecular proton transfer reactions in Kirby's enzyme models
1–7 reveal that the reaction rate is quite responsive to geometric disposition, especially to …