Human brain imaging studies have revealed several regions that are activated in patients
with chronic pain. In rodent brains, functional changes due to chronic pain have not been …

Application of functional imaging techniques to animal models is vital to understand pain
mechanisms, but is often confounded by the need to limit movement artefacts with …

Chronic pain often predicts the onset of psychological distress. Symptoms including anxiety
and depression after pain chronification reportedly are caused by brain remodeling …

Neuroimaging of pain in animals allows us to better understand mechanisms of pain
processing and modulation. In this review, we discuss recently published brain imaging …

Neuropathic pain induced by a nerve injury can lead to chronic pain. Recent studies have
reported hyperactive neural activities in the nociceptive-related area of the brain as a result …

Chronic pain is a major health problem, affecting 10–30% of the population in developed
countries. While chronic pain is defined as “a persistent complaint of pain lasting for more …

Manganese-enhanced magnetic resonance imaging (MEMRI) has been extensively used in
studying the structural and functional features of the central nervous system (CNS). Divalent …

As imaging technology develops, magnetic resonance imaging (MRI) has furthered our
understanding of brain function by clarifying the anatomical structure and generating …

Manganese-enhanced magnetic resonance imaging (MRI) is a surrogate method to
measure calcium content in nervous system since manganese physiologically follows …

Manganese-enhanced magnetic resonance imaging (MEMRI) is a powerful tool for in vivo
non-invasive whole-brain mapping of neuronal activity. Mn2+ enters active neurons via …