Our previous studies indicated that RhoA knockdown or inhibition could alleviate the
proliferation, migration, and differentiation of Schwann cells. However, the role of RhoA in …

RhoA is a small GTPase that regulates many functions of mammalian cells via actin
reorganization. Lots of studies uncovered that its activation acts as a major negative …

Background Plenty of macrophages are recruited to the injured nerve to play key roles in the
immunoreaction and engulf the debris of degenerated axons and myelin during Wallerian …

Paralysis following spinal cord injury (SCI) is due to failure of axonal regeneration. It is
believed that the capacities of neurons to regrow their axons are due partly to their intrinsic …

The Rho signaling pathway regulates the cytoskeleton and motility and plays an important
role in neuronal growth inhibition. Here we demonstrate that inactivation of Rho or its …

Neurons in the adult mammalian CNS do not spontaneously regenerate axons after injury
due to CNS myelin and other inhibitory factors. Previous studies have showed that inhibition …

Many axonal growth inhibitors that contribute to the usual failure of axon regeneration in the
central nervous system (CNS) exert their effects via the RhoA-Rho kinase (ROCK) signal …

Axons fail to regenerate in the adult central nervous system (CNS) following injury.
Developing strategies to promote axonal regeneration is therapeutically attractive for various …

Inhibiting RhoA-subfamily GTPases by C3 transferase is widely recognized as a prospective
strategy to enhance axonal regeneration. When C3 transferase is administered for treating …

RhoA, a member of Rho GTPases family, is known to play an important role in remodeling
actin cytoskeleton. During the development of the peripheral nervous system (PNS) …