Influx of sodium ions through voltage-gated sodium channels in cardiomyocytes is essential
for proper electrical conduction within the heart. Both acquired conditions associated with …

The cardiac sodium channel NaV1. 5, encoded by the SCN5A gene, is responsible for the
fast upstroke of the action potential. Mutations in SCN5A may cause sodium channel …

Cardiac voltage-gated sodium channel NaV1. 5, encoded by SCN5A, is crucial for the
upstroke of action potential and excitation of cardiomyocytes. NaV1. 5 undergoes complex …

The voltage-gated sodium channel 1.5 (Nav1. 5), encoded by the SCN5A gene, is
responsible for the rising phase of the action potential of cardiomyocytes. The sodium …

Cardiac Diseases Caused by SCN5A Mutations. A prerequisite for a normal cardiac function
is a proper generation and propagation of electrical impulses. Contraction of the heart is …

Abstract Background Mutations in SCN5A, the gene encoding the α-subunit of the cardiac
sodium channel (NaV1. 5), are associated with a broad spectrum of inherited cardiac …

To date, a large number of mutations in SCN5A, the gene encoding the pore-forming α-
subunit of the primary cardiac Na+ channel (NaV1. 5), have been found in patients …

Abstract Nav1. 5, the pore forming α-subunit of the voltage-dependent cardiac Na+ channel,
is an integral membrane protein involved in the initiation and conduction of action potentials …

Mutations of SCN5A gene, which encodes the α-subunit of the voltage-gated Na+ channel
NaV1. 5, underlie hereditary cardiac arrhythmic syndromes such as the type 3 long QT …

The gene SCN5A encodes the main cardiac sodium channel Na V 1.5. This channel
predominates the cardiac sodium current, I Na, which underlies the fast upstroke of the …