Ablation of C9orf72 together with excitotoxicity induces ALS in rats
W Dong, Y Ma, F Guan, X Zhang, W Chen… - The FEBS …, 2021 - Wiley Online Library
Pathogenesis of familial amyotrophic lateral sclerosis (ALS) linked to expansion of the
chromosome 9 open reading frame 72 (C9orf72) hexanucleotide repeat that impairs …
chromosome 9 open reading frame 72 (C9orf72) hexanucleotide repeat that impairs …
Knock in of a hexanucleotide repeat expansion in the C9orf72 gene induces ALS in rats
Abstract Background The GGGGCC (G4C2) repeat expansion in the human open reading
frame 72 on chromosome 9, C9orf72, is the most common cause of amyotrophic lateral …
frame 72 on chromosome 9, C9orf72, is the most common cause of amyotrophic lateral …
C 9orf72 ablation in mice does not cause motor neuron degeneration or motor deficits
M Koppers, AM Blokhuis, HJ Westeneng… - Annals of …, 2015 - Wiley Online Library
Objective How hexanucleotide (GGGGCC) repeat expansions in C9ORF72 cause
amyotrophic lateral sclerosis (ALS) remains poorly understood. Both gain‐and loss‐of …
amyotrophic lateral sclerosis (ALS) remains poorly understood. Both gain‐and loss‐of …
Cell-type specific differences in promoter activity of the ALS-linked C9orf72 mouse ortholog
A hexanucleotide repeat expansion in the C9orf72 gene is the most common cause of
inherited forms of the neurodegenerative disease amyotrophic lateral sclerosis (ALS). Both …
inherited forms of the neurodegenerative disease amyotrophic lateral sclerosis (ALS). Both …
Loss of function of C9orf72 causes motor deficits in a zebrafish model of amyotrophic lateral sclerosis
S Ciura, S Lattante, I Le Ber, M Latouche… - Annals of …, 2013 - Wiley Online Library
Objective To define the role that repeat expansions of a GGGGCC hexanucleotide sequence
of the C9orf72 gene play in the pathogenesis of amyotrophic lateral sclerosis (ALS) and …
of the C9orf72 gene play in the pathogenesis of amyotrophic lateral sclerosis (ALS) and …
C9orf72 deficiency promotes motor deficits of a C9ALS/FTD mouse model in a dose-dependent manner
G4C2 hexanucleotide repeat expansions in the first intron of C9ORF72 are the most
common cause of familial amyotrophic lateral sclerosis (ALS) and frontotemporal dementia …
common cause of familial amyotrophic lateral sclerosis (ALS) and frontotemporal dementia …
Synaptopathy mechanisms in ALS caused by C9orf72 repeat expansion
AL Nishimura, N Arias - Frontiers in cellular neuroscience, 2021 - frontiersin.org
Amyotrophic Lateral Sclerosis (ALS) is a complex neurodegenerative disease caused by
degeneration of motor neurons (MNs). ALS pathogenic features include accumulation of …
degeneration of motor neurons (MNs). ALS pathogenic features include accumulation of …
Isoform‐specific antibodies reveal distinct subcellular localizations of C 9orf72 in amyotrophic lateral sclerosis
S Xiao, L MacNair, P McGoldrick… - Annals of …, 2015 - Wiley Online Library
Objective A noncoding hexanucleotide repeat expansion in C9orf72 is the most common
cause of amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD) …
cause of amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD) …
Hyperactivity of Purkinje cell and motor deficits in C9orf72 knockout mice
A hexanucleotide (GGGGCC) repeat expansion in the first intron of the C9ORF72 gene is
the most frequently reported genetic cause of amyotrophic lateral sclerosis (ALS) and …
the most frequently reported genetic cause of amyotrophic lateral sclerosis (ALS) and …
ALS-associated C21ORF2 variant disrupts DNA damage repair, mitochondrial metabolism, neuronal excitability and NEK1 levels in human motor neurons
P Zelina, AA de Ruiter, C Kolsteeg… - Acta neuropathologica …, 2024 - Springer
Amyotrophic lateral sclerosis (ALS) is an adult-onset neurodegenerative disease leading to
motor neuron loss. Currently mutations in> 40 genes have been linked to ALS, but the …
motor neuron loss. Currently mutations in> 40 genes have been linked to ALS, but the …