[HTML][HTML] Reference compounds for alternative test methods to indicate developmental neurotoxicity (DNT) potential of chemicals: example lists and criteria for their …
M Aschner, S Ceccatelli, M Daneshian, E Fritsche… - Altex, 2017 - ncbi.nlm.nih.gov
There is a paucity of information concerning the developmental neurotoxicity (DNT) hazard
posed by industrial and environmental chemicals. New testing approaches will most likely …
posed by industrial and environmental chemicals. New testing approaches will most likely …
Developmental neurotoxicity testing: recommendations for developing alternative methods for the screening and prioritization of chemicals
KM Crofton, WR Mundy, PJ Lein, A Bal-Price… - ALTEX-Alternatives to …, 2011 - altex.org
Developmental neurotoxicity testing (DNT) is perceived by many stakeholders to be an area
in critical need of alternative methods to current animal testing protocols and guidelines. An …
in critical need of alternative methods to current animal testing protocols and guidelines. An …
International regulatory and scientific effort for improved developmental neurotoxicity testing
M Sachana, A Bal-Price, KM Crofton… - Toxicological …, 2019 - academic.oup.com
Abstract The Organisation for Economic Co-Operation and Development (OECD)
coordinates international efforts to enhance developmental neurotoxicity (DNT) testing. In …
coordinates international efforts to enhance developmental neurotoxicity (DNT) testing. In …
[HTML][HTML] Consensus statement on the need for innovation, transition and implementation of developmental neurotoxicity (DNT) testing for regulatory purposes
E Fritsche, P Grandjean, KM Crofton, M Aschner… - Toxicology and applied …, 2018 - Elsevier
This consensus statement voices the agreement of scientific stakeholders from regulatory
agencies, academia and industry that a new framework needs adopting for assessment of …
agencies, academia and industry that a new framework needs adopting for assessment of …
A 'best practices' approach to neuropathologic assessment in developmental neurotoxicity testing—for today
B Bolon, R Garman, K Jensen, G Krinke… - Toxicologic …, 2006 - journals.sagepub.com
A key trait of developmental neurotoxicants is their ability to cause structural lesions in the
immature nervous system. Thus, neuropathologic assessment is an essential element of …
immature nervous system. Thus, neuropathologic assessment is an essential element of …
[HTML][HTML] Strategies to improve the regulatory assessment of developmental neurotoxicity (DNT) using in vitro methods
A Bal-Price, F Pistollato, M Sachana, SK Bopp… - Toxicology and applied …, 2018 - Elsevier
Currently, the identification of chemicals that have the potential to induce developmental
neurotoxicity (DNT) is based on animal testing. Since at the regulatory level, systematic …
neurotoxicity (DNT) is based on animal testing. Since at the regulatory level, systematic …
Toward a better testing paradigm for developmental neurotoxicity: OECD efforts and regulatory considerations
M Sachana, TJ Shafer, A Terron - Biology, 2021 - mdpi.com
Simple Summary It is recognized that the current developmental neurotoxicity (DNT) testing
paradigm is not fit-for-purpose for the assessment of a large number of chemicals. In the last …
paradigm is not fit-for-purpose for the assessment of a large number of chemicals. In the last …
Literature review on in vitro and alternative developmental neurotoxicity (DNT) testing methods
E Fritsche, H Alm, J Baumann, L Geerts… - EFSA Supporting …, 2015 - Wiley Online Library
The goal of this systematic review performed under a contract with EFSA was the evaluation
of information on assessment methods in the field of developmental neurotoxicity (DNT) …
of information on assessment methods in the field of developmental neurotoxicity (DNT) …
[PDF][PDF] Conference Report: Advancing the Science of Developmental Neurotoxicity (DNT): Testing for Better Safety Evaluation.
AK Bal-Price, S Coecke, L Costa, KM Crofton… - Altex, 2012 - dash.harvard.edu
Conference Reports test Guidelines OPPtS 8706300 on DNt (US ePA, 1998) and in 2007
the Organization for economic Cooperation and Development (OeCD) endorsed a new …
the Organization for economic Cooperation and Development (OeCD) endorsed a new …
In vitro developmental neurotoxicity (DNT) testing: relevant models and endpoints
AK Bal-Price, HT Hogberg, L Buzanska, P Lenas… - Neurotoxicology, 2010 - Elsevier
Environmental chemicals have a potential impact on children's health as the developing
brain is much more vulnerable to injury caused by different classes of chemicals than the …
brain is much more vulnerable to injury caused by different classes of chemicals than the …
相关搜索
- testing assays developmental neurotoxicity
- neurotoxicity testing prioritization of chemicals
- oecd efforts developmental neurotoxicity
- regulatory assessment developmental neurotoxicity
- consensus statement developmental neurotoxicity
- safety evaluation developmental neurotoxicity
- testing paradigm developmental neurotoxicity
- testing and assessment developmental neurotoxicity
- regulatory purposes developmental neurotoxicity
- regulatory considerations developmental neurotoxicity