Clonal expansion of naive CD4 T cells is a necessary step in most adaptive immune
responses. Two distinct signals are required for clonal expansion to occur, ligation of T-cell …

Optimal induction of clonal expansion by normal CD4 T cells requires a ligand that can
engage the T cell receptor as well as functionally defined costimulatory activity on the same …

The maximal T-cell response to its antigen requires presentation of the antigen by a major
histocompatibility complex class II molecule as well as the delivery of one or more …

We used naive CD4 cells and in vitro-derived Th1 and Th2 effectors from TCR transgenic
mice to investigate the requirements of these subsets for TCR signaling and interactions with …

The zona pellucida (ZP), an ovarian extracellular structure, contains three major
glycoproteins: ZP1, ZP2, and ZP3. A ZP3 peptide contains both an autoimmune oophoritis …

The importance of CD28 costimulation to a primary T cell response in vivo was assessed in
an adoptive transfer system where a small population of peptide-specific CD4+ TCR …

We examined the role of accessory cell-derived signals in promoting growth and lymphokine
production by murine Th1 clones. Five of six Th1 clones failed to proliferate to immobilized …

Differentiation of naive CD4 T cells into cytokine-secreting effector Th1 and Th2 cells is
influenced by several factors. We have previously reported that the affinity of antigen for TCR …

The effect of stimulating normal type 1 murine T cell clones with anti-CD3 antibody was
examined in vitro. In the absence of accessory cells, anti-CD3 antibody immobilized on …

For T cells to be optimally activated, recognition of Ag/MHC complexes by the TCR must be
accompanied by a second, costimulatory signal that can be provided efficiently by the …