Efficient migration of macrophages to sites of inflammation requires cell surface–bound
plasmin (ogen). Here, we investigated the mechanisms underlying the deficits of plasmin …

It is widely held that the plasminogen (Plg) system plays a role in inflammation through
plasmin-mediated directional cell migration. However, substantial evidence for its …

Leukocyte migration is the hallmark of inflammation, and integrin αMβ2 and its ligand
fibrinogen (Fg) are key participants in this cellular response. Cells expressing wild-type or …

In addition to its participation in fibrinolysis, plasminogen is believed to play an important
role in mediating cell migration. The development of mice in which the plasminogen gene …

Inflammation plays a critical role in the development of cardiovascular diseases. Infiltration
of leukocytes to sites of injury requires their exit from the blood and migration across …

The phagocytic function of macrophages plays a pivotal role in eliminating apoptotic cells
and invading pathogens. Evidence implicating plasminogen (Plg), the zymogen of plasmin …

The plasminogen (Plg)/plasmin (Pla) system is associated with a variety of biological
activities beyond the classical dissolution of fibrin clots, including cell migration, tissue …

Recruitment of leukocytes from blood to tissue in inflammation requires the function of
specific cell surface adhesion molecules. The objective of this study was to identify adhesion …

Objective—Macrophage (Mφ) migration rests on the adhesion/detachment between Mφ
surface components and extracellular matrixes, and the contribution of numerous …

Cell adhesion molecules are critically involved in the multistep process of leukocyte
recruitment in inflammation. The specific receptors used by polymorphonuclear leukocytes …