MeCP2 links heterochromatin condensates and neurodevelopmental disease
Abstract Methyl CpG binding protein 2 (MeCP2) is a key component of constitutive
heterochromatin, which is crucial for chromosome maintenance and transcriptional …
heterochromatin, which is crucial for chromosome maintenance and transcriptional …
Radically truncated MeCP2 rescues Rett syndrome-like neurological defects
R Tillotson, J Selfridge, MV Koerner, KKE Gadalla… - Nature, 2017 - nature.com
Heterozygous mutations in the X-linked MECP2 gene cause the neurological disorder Rett
syndrome. The methyl-CpG-binding protein 2 (MeCP2) protein is an epigenetic reader …
syndrome. The methyl-CpG-binding protein 2 (MeCP2) protein is an epigenetic reader …
Deficiency of methyl-CpG binding protein-2 in CNS neurons results in a Rett-like phenotype in mice
RZ Chen, S Akbarian, M Tudor, R Jaenisch - Nature genetics, 2001 - nature.com
Mecp2 is an X-linked gene encoding a nuclear protein that binds specifically to methylated
DNA (ref. 1) and functions as a general transcriptional repressor by associating with …
DNA (ref. 1) and functions as a general transcriptional repressor by associating with …
Rett syndrome-causing mutations compromise MeCP2-mediated liquid–liquid phase separation of chromatin
Rett syndrome (RTT), a severe postnatal neurodevelopmental disorder, is caused by
mutations in the X-linked gene encoding methyl-CpG-binding protein 2 (MeCP2). MeCP2 is …
mutations in the X-linked gene encoding methyl-CpG-binding protein 2 (MeCP2). MeCP2 is …
Loss of silent-chromatin looping and impaired imprinting of DLX5 in Rett syndrome
Mutations in MECP2 are associated with Rett syndrome, an X-linked neurodevelopmental
disorder. To identify genes targeted by Mecp2, we sequenced 100 in vivo Mecp2-binding …
disorder. To identify genes targeted by Mecp2, we sequenced 100 in vivo Mecp2-binding …
Reversal of phenotypes in MECP2 duplication mice using genetic rescue or antisense oligonucleotides
Y Sztainberg, H Chen, JW Swann, S Hao, B Tang… - Nature, 2015 - nature.com
Copy number variations have been frequently associated with developmental delay,
intellectual disability and autism spectrum disorders. MECP2 duplication syndrome is one of …
intellectual disability and autism spectrum disorders. MECP2 duplication syndrome is one of …
MeCP2 binds cooperatively to its substrate and competes with histone H1 for chromatin binding sites
RP Ghosh, RA Horowitz-Scherer… - … and cellular biology, 2010 - Am Soc Microbiol
Sporadic mutations in the hMeCP2 gene, coding for a protein that preferentially binds
symmetrically methylated CpGs, result in the severe neurological disorder Rett syndrome …
symmetrically methylated CpGs, result in the severe neurological disorder Rett syndrome …
A role for glia in the progression of Rett's syndrome
DT Lioy, SK Garg, CE Monaghan, J Raber, KD Foust… - Nature, 2011 - nature.com
Rett's syndrome (RTT) is an X-chromosome-linked autism spectrum disorder caused by loss
of function of the transcription factor methyl-CpG-binding protein 2 (MeCP2). Although …
of function of the transcription factor methyl-CpG-binding protein 2 (MeCP2). Although …
A mouse Mecp2-null mutation causes neurological symptoms that mimic Rett syndrome
Rett syndrome (RTT) is an inherited neurodevelopmental disorder of females that occurs
once in 10,000–15,000 births 1, 2. Affected females develop normally for 6–18 months, but …
once in 10,000–15,000 births 1, 2. Affected females develop normally for 6–18 months, but …
Activity-dependent phosphorylation of MeCP2 threonine 308 regulates interaction with NCoR
Rett syndrome (RTT) is an X-linked human neurodevelopmental disorder with features of
autism and severe neurological dysfunction in females. RTT is caused by mutations in …
autism and severe neurological dysfunction in females. RTT is caused by mutations in …