In recent decades, dysregulation of proteases and atypical proteolysis have become
increasingly recognized as important hallmarks of cancer, driving community-wide efforts to …

Proteolysis plays critical roles in normal and pathologic physiology; these enzymes are
intricately involved in cancer progression and spread. Our understanding of protease …

The role of proteases in cancer was originally thought to be limited to the breakdown of
basement membranes and extracellular matrix (ECM), thereby promoting cancer cell …

The roles of proteases in cancer are dynamic. Furthermore, the roles or functions of any one
protease may differ from one stage of cancer to another. Proteases from tumor-associated …

Proteases are considered of major importance in biomedical research because of their
crucial roles in health and disease. Their ability to hydrolyze their protein and peptide …

Proteases irreversibly modify proteins by cleaving their amide bonds and are implicated in
virtually every important biological process such as immunity, development and tissue …

Proteolysis constitutes a major post-translational modification but specificity and substrate
selectivity of numerous proteases have remained elusive. In this review, we highlight how …

Proteases have long been associated with cancer progression because of their ability to
degrade extracellular matrices, which facilitates invasion and metastasis. However, recent …

Proteostasis is the process of regulating intracellular proteins to maintain the balance of the
cell proteome, which is crucial for cancer cell survival. Several proteases located in the …

The early detection of both primary tumors and metastatic disease continue to be significant
challenges in the diagnosis and staging of cancer. The growing recognition of the role of …