Prevention of loperamide induced constipation in mice by KGM and the mechanisms of different gastrointestinal tract microbiota regulation

Q Zhang, D Zhong, R Sun, Y Zhang, RB Pegg… - Carbohydrate …, 2021 - Elsevier
Constipation is one of the most prevalent gastrointestinal tract diseases. Konjac
glucomannan (KGM) dietotherapy can effectively relieve the clinical symptoms of patients …

Amelioration of gut dysbiosis and gastrointestinal motility by konjac oligo-glucomannan on loperamide-induced constipation in mice

F Hayeeawaema, S Wichienchot, P Khuituan - Nutrition, 2020 - Elsevier
Objective Konjac oligo-glucomannan (KOG) is a non-digestible dietary fiber that is resistant
to digestion and absorption in gastrointestinal (GI) tract. Thus, it might be used as an …

Effect of konjac glucomannan on metabolites in the stomach, small intestine and large intestine of constipated mice and prediction of the KEGG pathway

Q Zhang, D Zhong, YY Ren, Z Meng, RB Pegg… - Food & Function, 2021 - pubs.rsc.org
The occurrence of constipation involves the whole gastrointestinal tract. Konjac
glucomannan (KGM) has been clinically proven to alleviate constipation, but its mechanism …

Konjac glucomannan with probiotics acts as a combination laxative to relieve constipation in mice by increasing short-chain fatty acid metabolism and 5 …

Y Lu, J Zhang, Z Zhang, X Liang, T Liu, H Yi, P Gong… - Nutrition, 2021 - Elsevier
Objectives Various probiotics and natural products can help to relieve constipation. This
study aimed to explore the constipation-relieving effects and potential mechanism of a …

Changes in the gut microbiome after galacto-oligosaccharide administration in loperamide-induced constipation

MG Kim, K Jo, YB Chang, HJ Suh, KB Hong - Journal of Personalized …, 2020 - mdpi.com
Unbalanced dietary habits and the consumption of high protein and instant foods cause an
increase in constipation. Here, we evaluated the effects of galacto-oligosaccharide (GOS) on …

Chitosan oligosaccharides attenuate loperamide-induced constipation through regulation of gut microbiota in mice

X Zhang, H Yang, J Zheng, N Jiang, G Sun, X Bao… - Carbohydrate …, 2021 - Elsevier
This study was designed to explore the improvement of chitosan oligosaccharides (COS) on
constipation through regulation of gut microbiota. Here, we proved that COS treatment …

Comparison of the laxative effects of Korean Gochujang containing different microbiota on loperamide-induced constipation in ICR mice

NY Kim, KA Kim, HJ Yang, SJ Jeong, A Han… - Food & Function, 2023 - pubs.rsc.org
The prevalence of constipation, one of the common gastrointestinal (GI) diseases, has been
gradually increasing. Gochujang, a traditional Korean fermented paste, has various …

Effect of Konjac mannan oligosaccharides on diphenoxylate-induced constipation in mice

X Liu, S Chen, Q Yan, Y Li, Z Jiang - Journal of functional foods, 2019 - Elsevier
The effects of Konjac mannan oligosaccharides (KMOS) on diphenoxylate-induced
constipation in mice were investigated in the present study. After administration with KMOS …

Modulation of gut microbiota and intestinal metabolites by lactulose improves loperamide-induced constipation in mice

X Zhang, J Zheng, N Jiang, G Sun, X Bao… - European Journal of …, 2021 - Elsevier
Lactulose is a common laxative and has been widely applied to clinical treatment for
constipation. This study aimed to explore the improving effect of lactulose on constipation …

Hypoglycemic effects of different molecular weight konjac glucomannans via intestinal microbiota and SCFAs mediated mechanism

J Deng, X Zou, Y Liang, J Zhong, K Zhou… - International Journal of …, 2023 - Elsevier
The hypoglycemic effects of konjac glucomannans (KGMs) are well recognized, and our
previous study showed KGMs with different molecular weight have different hypoglycemic …