Thymoquinone radiosensitizes human colorectal cancer cells in 2D and 3D culture models

S Al Bitar, F Ballout, A Monzer, M Kanso, N Saheb… - Cancers, 2022 - mdpi.com
Simple Summary Radiotherapy is a standard of care therapy that kills cancer cells but has
limited efficacy in targeting the resistant cancer stem cells (CSCs). The use of …

[HTML][HTML] Thymoquinone induces apoptosis and DNA damage in 5-Fluorouracil-resistant colorectal cancer stem/progenitor cells

F Ballout, A Monzer, M Fatfat, H El Ouweini, MA Jaffa… - Oncotarget, 2020 - ncbi.nlm.nih.gov
The high recurrence rates of colorectal cancer have been associated with a small population
of cancer stem cells (CSCs) that are resistant to the standard chemotherapeutic drug, 5 …

Thymoquinone reduces mouse colon tumor cell invasion and inhibits tumor growth in murine colon cancer models

H Gali‐Muhtasib, M Ocker, D Kuester… - Journal of cellular …, 2008 - Wiley Online Library
We have shown that thymoquinone (TQ) is a potent antitumor agent in human colorectal
cancer cells. In this study, we evaluated TQ's therapeutic potential in two different mice colon …

Potential anticancer properties and mechanisms of thymoquinone in colorectal cancer

F Sheikhnia, V Rashidi, H Maghsoudi… - Cancer Cell …, 2023 - Springer
Colorectal neoplasms are one of the deadliest diseases among all cancers worldwide.
Thymoquinone (TQ) is a natural compound of Nigella sativa that has been used in traditional …

Anticancer and anti-metastatic role of thymoquinone: Regulation of oncogenic signaling cascades by thymoquinone

AA Farooqi, R Attar, B Xu - International Journal of Molecular Sciences, 2022 - mdpi.com
Cancer is a life-threatening and multifaceted disease. Pioneering research works in the past
three decades have mechanistically disentangled intertwined signaling networks which play …

[HTML][HTML] Therapeutic potential of thymoquinone in combination therapy against cancer and cancer stem cells

Z Fatfat, M Fatfat, H Gali-Muhtasib - World journal of clinical …, 2021 - ncbi.nlm.nih.gov
The long-term success of standard anticancer monotherapeutic strategies has been
hampered by intolerable side effects, resistance to treatment and cancer relapse. These …

A multiple endpoint approach reveals potential in vitro anticancer properties of thymoquinone in human renal carcinoma cells

JG Costa, V Keser, C Jackson, N Saraiva… - Food and chemical …, 2020 - Elsevier
Thymoquinone (TQ) is a monoterpene isolated from the oil of Nigella sativa seeds. The aim
of this work was to evaluate the cytotoxic effects induced by TQ and its impact on the …

[HTML][HTML] Thymoquinone suppresses cellular proliferation, inhibits VEGF production and obstructs tumor progression and invasion in the rat model of DMH-induced …

W Asfour, S Almadi, L Haffar - 2013 - scirp.org
A myriad of medicinal effects has been attributed to Thymoquinone (TQ), the major
biological-active component of Nigella sativa. TQ has been shown to exhibit potent anti …

Radiosensitization in human breast carcinoma cells by thymoquinone: role of cell cycle and apoptosis

R Velho‐Pereira, A Kumar, BN Pandey… - Cell biology …, 2011 - Wiley Online Library
TQ (thymoquinone), the bioactive constituent of black seed (Nigella sativa), has been shown
to inhibit the growth of various human cancers both in vitro and in vivo. This study reports the …

Review on molecular and therapeutic potential of thymoquinone in cancer

S Banerjee, S Padhye, A Azmi, Z Wang… - Nutrition and …, 2010 - Taylor & Francis
Thymoquinone (TQ) is the predominant bioactive constituent present in black seed oil
(Nigella sativa) and has been tested for its efficacy against cancer. Here, we summarize the …