Tolerance and innate immunity shape the development of postpartum uterine disease and the impact of endometritis in dairy cattle

IM Sheldon, JG Cronin… - Annual review of animal …, 2019 - annualreviews.org
Bacteria are ubiquitous in the bovine uterus after parturition, but 50 years ago, cows
tolerated these bacteria and few animals developed uterine disease. Now, up to 40% of …

Preventing postpartum uterine disease in dairy cattle depends on avoiding, tolerating and resisting pathogenic bacteria

IM Sheldon, PCC Molinari, TJR Ormsby, JJ Bromfield - Theriogenology, 2020 - Elsevier
Up to forty percent of dairy cows develop metritis or endometritis when pathogenic bacteria
infect the uterus after parturition. However, resilient cows remain healthy even when …

Postpartum uterine infection and endometritis in dairy cattle

IM Sheldon, SE Owens - Animal Reproduction (AR), 2018 - animal-reproduction.org
After parturition, uterine involution, regeneration of the endometrium, return of ovarian cyclic
activity, and the control of pathogenic bacteria in the uterus is required before cows are likely …

Mechanisms linking bacterial infections of the bovine endometrium to disease and infertility

LC Carneiro, JG Cronin, IM Sheldon - Reproductive biology, 2016 - Elsevier
Bacterial infections of the endometrium after parturition commonly cause metritis and
endometritis in dairy cattle, and these diseases are important because they compromise …

Expression of genes associated with immunity in the endometrium of cattle with disparate postpartum uterine disease and fertility

S Herath, ST Lilly, NR Santos, RO Gilbert… - Reproductive Biology …, 2009 - Springer
Background Contamination of the uterine lumen with bacteria is ubiquitous in cattle after
parturition. Some animals develop endometritis and have reduced fertility but others have no …

Reproductive tract defense and disease in postpartum dairy cows

SJ LeBlanc, T Osawa, J Dubuc - Theriogenology, 2011 - Elsevier
This paper briefly reviews recent data and concepts on the development and mitigation of
infection and inflammation in the reproductive tract of dairy cows during the first 2 mo after …

Defining postpartum uterine disease and the mechanisms of infection and immunity in the female reproductive tract in cattle

IM Sheldon, J Cronin, L Goetze, G Donofrio… - Biology of …, 2009 - academic.oup.com
Uterine microbial disease affects half of all dairy cattle after parturition, causing infertility by
disrupting uterine and ovarian function. Infection with Escherichia coli, Arcanobacterium …

PHYSIOLOGY AND ENDOCRINOLOGY SYMPOSIUM: Uterine infection: Linking infection and innate immunity with infertility in the high-producing dairy cow,

JJ Bromfield, JEP Santos, J Block… - Journal of animal …, 2015 - academic.oup.com
Uterine contamination with bacteria is ubiquitous in the postpartum dairy cow. Nearly one-
half of all postpartum dairy cows develop clinical disease resulting in metritis and …

Uterine health and disorders

GS Lewis - Journal of dairy science, 1997 - Elsevier
Nonspecific uterine infections reduce the reproductive efficiency of cows and the profit
potential of dairy farms. Fortunately, most cows do not develop severe uterine infections. The …

Modulation of immune function in the bovine uterus peripartum

OB Pascottini, SJ LeBlanc - Theriogenology, 2020 - Elsevier
There is a high risk of clinical or subclinical reproductive tract disease in the postpartum
period in dairy cows. An integrated process of adaptive events should occur synchronously …